http://www.cnr.it/ontology/cnr/individuo/prodotto/ID184333

Identification of Acromegalic Patients at Risk of Developing Colonic Adenomas (Articolo in rivista)

Type

Prodotto della ricerca (Classe)
Articolo in rivista (Classe)

Label

Identification of Acromegalic Patients at Risk of Developing Colonic Adenomas (Articolo in rivista) (literal)

Anno

2006-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1210/jc.2005-2500 (literal)

Alternative label

Fausto Bogazzi; Chiara Cosci; Chiara Sardella; Aurelio Costa; Luca Manetti; Maurizio Gasperi; Giuseppe Rossi; Luigi Bartalena; and Enio Martino (2006)
Identification of Acromegalic Patients at Risk of Developing Colonic Adenomas
in The Journal of clinical endocrinology and metabolism; Endocrine Society, Chevy Chase (Stati Uniti d'America)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Fausto Bogazzi; Chiara Cosci; Chiara Sardella; Aurelio Costa; Luca Manetti; Maurizio Gasperi; Giuseppe Rossi; Luigi Bartalena; and Enio Martino (literal)

Pagina inizio

1351 (literal)

Pagina fine

1356 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

91 (literal)

Rivista

?The ?Journal of clinical endocrinology and metabolism (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

6 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

4 (literal)

Note

ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

Departments of Endocrinology and Metabolism (F.B., C.C., C.S., L.M., M.G., E.M.) and Oncology (A.C.), University of Pisa,56124 Pisa, Italy; Unit of Epidemiology and Biostatistics (G.R.), Institute of Clinical Physiology, National Research Council, 56124 Pisa, Italy; Department of Clinical Medicine (L.B.), University of Insubria, 21100 Varese, Italy (literal)

Titolo

Identification of Acromegalic Patients at Risk of Developing Colonic Adenomas (literal)

Abstract

Background: Acromegaly seems to be associated with an increased prevalence of colonic adenomas, although factors affecting their development and recurrence of the latter are not fully known. Subjects and Methods: Seventy-nine patients with active acromegaly were prospectively followed up for 5 yr. Two hundred eighty healthy subjects served as controls. Colonoscopy and assessment of acromegaly activity were performed at 1-yr intervals. Acromegaly was defined as controlled if serum IGF-I levels were within the normal age-adjusted range. Results: Colonic adenomas were found in 26 of 79 acromegalic patients (32.9%) and 60 of 280 controls (21.4%) at baseline (P ? 0.035, adjusted for age and sex, odds ratio 1.82, 95% confidence interval, 1.02-3.25). Seven patients had hyperplastic polyps; the remaining 46 acromegalic patients had no detectable lesions at baseline and did not develop adenomas during the study period. Of the 26 patients with colonic adenomas at baseline, 16 (61.5%) had at least one recurrence of colonic adenomas (P ? 0.0001 vs. patients without colonic lesions at baseline), and multiple recurrences were more frequent in patients with uncontrolled acromegaly (66.7% vs. 17.6% in patients with controlled acromegaly, P ? 0.028). Conclusions: The first colonoscopy helps to identify acromegalic patients at high risk of developing colonic adenomas. If colonic adenomas are not present initially, it is unlikely that they develop thereafter, independently of metabolic control of acromegaly. Conversely, new lesions are frequent (and often multiple) in patients who already have colonic adenomas at baseline, particularly if acromegalic disease is poorly controlled by treatment. (literal)

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