Area-specific temporal control of corticospinal motor neuron differentiation by COUP-TFI (Articolo in rivista)

Type
Label
  • Area-specific temporal control of corticospinal motor neuron differentiation by COUP-TFI (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1073/pnas.0911792107 (literal)
Alternative label
  • Giulio Srubek Tomassya; Elvira De Leonibusa; Denis Jabaudonc; Simona Lodatoa; Christian Alfanoa; Andrea Mele; Jeffrey D. Macklisc; Michèle Studer (2010)
    Area-specific temporal control of corticospinal motor neuron differentiation by COUP-TFI
    in Proceedings of the National Academy of Sciences of the United States of America
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Giulio Srubek Tomassya; Elvira De Leonibusa; Denis Jabaudonc; Simona Lodatoa; Christian Alfanoa; Andrea Mele; Jeffrey D. Macklisc; Michèle Studer (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • aTelethon Institute of Genetics and Medicine, Developmental Disorders Program, 80131 Naples, Italy; bLaboratory of Psychobiology, Department of Genetics and Molecular Biology, University of Rome, 00185 Rome, Italy; cMassachusetts General Hospital-Harvard Medical School Center for Nervous System Repair, Departments of Neurosurgery and Neurology, and Program in Neuroscience, Harvard Medical School, Nayef Al-Rodhan Laboratories, Massachusetts General Hospital, and Department of Stem Cell and Regenerative Biology, and Harvard Stem Cell Institute, Harvard University, Boston, MA 02114; dDepartment of Basic Neurosciences, and Clinic of Neurology, University of Geneva, Geneva, Switzerland; and eInserm U636, and Université de Nice-Sophia Antipolis, Laboratoire de Génétique du Développement Normal et Pathologique, F-06108 Nice, France (literal)
Titolo
  • Area-specific temporal control of corticospinal motor neuron differentiation by COUP-TFI (literal)
Abstract
  • Transcription factors with gradients of expression in neocortical progenitors give rise to distinct motor and sensory cortical areas by controlling the area-specific differentiation of distinct neuronal subtypes. However, the molecular mechanisms underlying this area-restricted control are still unclear. Here, we show that COUPTFI controls the timing of birth and specification of corticospinal motor neurons (CSMN) in somatosensory cortex via repression of a CSMN differentiation program. Loss of COUP-TFI function causes an area-specific premature generation of neurons with cardinal features of CSMN, which project to subcerebral structures, including the spinal cord. Concurrently, genuine CSMN differentiate imprecisely and do not project beyond the pons, together resulting in impaired skilled motor function in adult mice with cortical COUP-TFI loss-of-function. Our findings indicate that COUP-TFI exerts critical areal and temporal control over the precise differentiation of CSMN during corticogenesis, thereby enabling the area-specific functional features of motor and sensory areas to arise. (literal)
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