F(2)-dihomo-isoprostanes as potential early biomarkers of lipid oxidative damage in Rett syndrome (Articolo in rivista)

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  • F(2)-dihomo-isoprostanes as potential early biomarkers of lipid oxidative damage in Rett syndrome (Articolo in rivista) (literal)
Anno
  • 2011-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1194/jlr.P017798 (literal)
Alternative label
  • De Felice, C; Signorini, C; Durand, T; Oger, C; Guy, A; Bultel-Ponce, V; Galano, JM; Ciccoli, L; Leoncini, S; D'Esposito, M; Filosa, S; Pecorelli, A; Valacchi, G; Hayek, J (2011)
    F(2)-dihomo-isoprostanes as potential early biomarkers of lipid oxidative damage in Rett syndrome
    in Journal of lipid research (Print); American Society Of Biochemistry And Molecular Biology Inc. (ASBMB), Rockville (Stati Uniti d'America)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • De Felice, C; Signorini, C; Durand, T; Oger, C; Guy, A; Bultel-Ponce, V; Galano, JM; Ciccoli, L; Leoncini, S; D'Esposito, M; Filosa, S; Pecorelli, A; Valacchi, G; Hayek, J (literal)
Pagina inizio
  • 2287 (literal)
Pagina fine
  • 2297 (literal)
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  • 52 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 12 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Azienda Osped Univ Senese, Univ Hosp, Neonatal Intens Care Unit, Siena, Italy Azienda Osped Univ Senese, Univ Hosp, Child Neuropsychiat Unit, Siena, Italy Univ Siena, Dept Pathophysiol Expt Med & Publ Hlth, I-53100 Siena, Italy UMR 5247 CNRS UM I UM II, Inst Biomol Max Mousseron, Montpellier, France CNR, Inst Genet & Biophys Adriano Buzzati Traverso, I-80125 Naples, Italy Univ Ferrara, Dept Evolutionary Biol, I-44100 Ferrara, Italy Ist Neurol Mediterraneo Neuromed, Pozzilli, Italy Kyung Hee Univ, Dept Food & Nutr, Seoul, South Korea (literal)
Titolo
  • F(2)-dihomo-isoprostanes as potential early biomarkers of lipid oxidative damage in Rett syndrome (literal)
Abstract
  • Oxidative damage has been reported in Rett syndrome (RTT), a pervasive developmental disorder caused in up to 95% of cases by mutations in the X-linked methyl-CpG binding protein 2 gene. Herein, we have synthesized F(2)-dihomo-isoprostanes (F(2)-dihomo-IsoPs), peroxidation products from adrenic acid (22:4 n-6), a known component of myelin, and tested the potential value of F(2)-dihomo-IsoPs as a novel disease marker and its relationship with clinical presentation and disease progression. F(2)-dihomo-IsoPs were determined by gas chromatography/negative-ion chemical ionization tandem mass spectrometry. Newly synthesized F(2)-dihomo-IsoP isomers [ent-7(RS)-F(2t)-dihomo-IsoP and 17-F(2t)-dihomo-IsoP] were used as reference standards. The measured ions were the product ions at m/z 327 derived from the [M-181](-) precursor ions (m/z 597) produced from both the derivatized ent-7(RS)-F(2t)-dihomo-IsoP and 17-F(2t)-dihomo-IsoP. Average plasma F(2)-dihomo-IsoP levels in RTT were about one order of magnitude higher than those in healthy controls, being higher in typical RTT as compared with RTT variants, with a remarkable increase of about two orders of magnitude in patients at the earliest stage of the disease followed by a steady decrease during the natural clinical progression. These data indicate for the first time that quantification of F(2)-dihomo-IsoPs in plasma represents an early marker of the disease and may provide a better understanding of the pathogenic mechanisms behind the neurological regression in patients with RTT.-De Felice, C., C. Signorini, T. Durand, C. Oger, A. Guy, V. Bultel-Ponce, J-M. Galano, L. Ciccoli, S. Leoncini, M. D'Esposito, S. Filosa, A. Pecorelli, G. Valacchi, and J. Hayek. F(2)-dihomo-isoprostanes as potential early biomarkers of lipid oxidative damage in Rett syndrome (literal)
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