Risk profiles in type 2 diabetes (metabolic syndrome): integration of IL-10 polymorphisms and laboratory parameters to identify vascular damages related complications (Articolo in rivista)

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  • Risk profiles in type 2 diabetes (metabolic syndrome): integration of IL-10 polymorphisms and laboratory parameters to identify vascular damages related complications (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Alternative label
  • Forte GI; Pilato G; Vaccarino L; Sanacore M; Candore G; Romano GC; Testa R; Ranceschi C; Capri M; Marra M; Bonfigli AR; Caruso C; Scola L; Lio D (2010)
    Risk profiles in type 2 diabetes (metabolic syndrome): integration of IL-10 polymorphisms and laboratory parameters to identify vascular damages related complications
    in Current pharmaceutical design (Print); Bentham Science Publishers Ltd., Sharjah (Emirati Arabi Uniti)
    (literal)
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  • Forte GI; Pilato G; Vaccarino L; Sanacore M; Candore G; Romano GC; Testa R; Ranceschi C; Capri M; Marra M; Bonfigli AR; Caruso C; Scola L; Lio D (literal)
Pagina inizio
  • 898 (literal)
Pagina fine
  • 903 (literal)
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  • 16 (literal)
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  • 7 (literal)
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  • PubMe (literal)
  • ISI Web of Science (WOS) (literal)
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  • Gruppo di studio sull'Immunosenescenza; Dipartimento di Biopatologia e Metodologie Biomediche, Università di Palermo; Istituto di Calcolo e Reti ad Alta Prestazione ICAR CNR, Palermo, Italy. (literal)
Titolo
  • Risk profiles in type 2 diabetes (metabolic syndrome): integration of IL-10 polymorphisms and laboratory parameters to identify vascular damages related complications (literal)
Abstract
  • Recently it has been reported that low serum IL-10 levels are associated with an increased susceptibility for metabolic syndrome and type 2 diabetes mellitus (T2DM). We investigated whether the -1087G/A (rs1800896), -824C/T (rs1800871), -597C/A (rs1800872) IL-10 polymorphisms were associated with type 2 diabetes in a study on a cohort of Italian Caucasians comprising 490 type 2 diabetic and 349 control subjects. Stratifying the data according to IL-10 genotypes, trends for the progressive increase of glucose and neutrophil levels were observed in -1087GG vs. -1087GA vs. -1087AA positive diabetic patients (-1087GG<-1087GA<-1087AA). In addition, evaluating the laboratory parameters according to the -597/-824/-1087 derived haplotypes a significant increase of neutrophils was found in diabetic vs. non-diabetic -597A/ -824T/-1087A positive subjects (Student t test = 3.707, p<0.01). In an attempt to integrate clinical laboratory and immunogenetic data to determine whether these factors taken together define sufficient risk sets for type 2 diabetes we performed the grade-of-membership analysis (GoM). GoM allowed to identify a population of subjects negative for IL-10 - 824T allele, 74.4% of which were diabetic patients characterised by vascular damages (Chronic kidney failure and/or Myocardial Infarction), reduction of haematocrit, increase of blood urea nitrogen, creatinin and monocyte levels. These data seem to suggest that - 597A/-824T/-1087A negative subjects are more prone to the major type 2 diabetic vascular damages and allow to hypothesise that the contemporary evaluation of some simple hematochemical parameters and IL-10 SNPs may allow identifying diabetic patients with the worse prognostic profile, needing both better complication prevention planning and therapeutic strategies. (literal)
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