Brain-derived neurotrophic factor (BDNF) overexpression in the forebrain results in learning and memory impairments (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Brain-derived neurotrophic factor (BDNF) overexpression in the forebrain results in learning and memory impairments (Articolo in rivista) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.nbd.2008.11.004 (literal)

Alternative label

• Cunha, C (Cunha, Carla)1,2; Angelucci, A (Angelucci, Andrea)3; D'Antoni, A (D'Antoni, Angela)1,4; Dobrossy, MD (Dobrossy, Mate D.)5; Dunnett, SB (Dunnett, Stephen B.)5; Berardi, N (Berardi, Nicoletta)3,6; Brambilla, R (Brambilla, Riccardo)1 (2008)
  Brain-derived neurotrophic factor (BDNF) overexpression in the forebrain results in learning and memory impairments
  in Neurobiology of disease; Elsevier, Amsterdam (Paesi Bassi)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Cunha, C (Cunha, Carla)1,2; Angelucci, A (Angelucci, Andrea)3; D'Antoni, A (D'Antoni, Angela)1,4; Dobrossy, MD (Dobrossy, Mate D.)5; Dunnett, SB (Dunnett, Stephen B.)5; Berardi, N (Berardi, Nicoletta)3,6; Brambilla, R (Brambilla, Riccardo)1 (literal)

Pagina inizio

• 358 (literal)

Pagina fine

• 368 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.sciencedirect.com/science/article/pii/S0969996108002775 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 33 (literal)

Rivista

• Neurobiology of disease (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 3 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1. Ist Sci San Raffaele, I-20132 Milan, Italy 2. Univ Porto, Fac Ciencias, Oporto, Portugal 3. CNR, Inst Neurosci, I-56100 Pisa, Italy 4. Univ Milan, I-20122 Milan, Italy 5. Sch Biosci, Cardiff, S Glam, Wales 6. Univ Florence, Dept Psychol, Florence, Italy (literal)

Titolo

• Brain-derived neurotrophic factor (BDNF) overexpression in the forebrain results in learning and memory impairments (literal)

Abstract

• In this study we analyzed the effect on behavior of a chronic exposure to brain-derived neurotrophic factor (BDNF), by analysing a mouse line overexpressing BDNF under the (alpha CaMKII promoter, which drives the transgene expression exclusively to principal neurons of the forebrain. BDNF transgenic mice and their WT littermates were examined with a battery of behavioral tests, in order to evaluate motor coordination, learning, short and long-term memory formation. Our results demonstrate that chronic BDNF overexpression in the central nervous system (CNS) causes learning deficits and short-term memory impairments, both in spatial and instrumental learning tasks. This observation suggests that a widespread increase in BDNF in forebrain networks may result in adverse effects on learning and memory formation. (literal)

Editore

• Elsevier (Editore)

Prodotto di

• Istituto di neuroscienze (IN) (Istituto)

Autore CNR

• NICOLETTA BERARDI (Unità di personale esterno)
• ANDREA ANGELUCCI (Persona)

Insieme di parole chiave

• Keywords of "Brain-derived neurotrophic factor (BDNF) overexpression in the forebrain results in learning and memory impairments" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di neuroscienze (IN) (Istituto)

Autore CNR di

• ANDREA ANGELUCCI (Persona)
• NICOLETTA BERARDI (Unità di personale esterno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Neurobiology of disease (Rivista)

Editore di

• Elsevier (Editore)

Insieme di parole chiave di

• Keywords of "Brain-derived neurotrophic factor (BDNF) overexpression in the forebrain results in learning and memory impairments" (Insieme di parole chiave)