High-yield synthesis of the terminal 188Re(N) multiple bond from generator-produced [188ReO4]- (Articolo in rivista)

Type
Label
  • High-yield synthesis of the terminal 188Re(N) multiple bond from generator-produced [188ReO4]- (Articolo in rivista) (literal)
Anno
  • 2003-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/S0969-8051(03)00002-7 (literal)
Alternative label
  • Boschi, A.; Bolzati, C.; Uccelli, L.; Duatti, A. (2003)
    High-yield synthesis of the terminal 188Re(N) multiple bond from generator-produced [188ReO4]-
    in Nuclear medicine and biology
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Boschi, A.; Bolzati, C.; Uccelli, L.; Duatti, A. (literal)
Pagina inizio
  • 381 (literal)
Pagina fine
  • 387 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.sciencedirect.com/science/article/pii/S0969805103000027 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 30 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • (1,3,4). Laboratory of Nuclear Medicine, Department of Clinical & Experimental Medicine, University of Ferrara (2) ICIS - CNR - Padova (literal)
Titolo
  • High-yield synthesis of the terminal 188Re(N) multiple bond from generator-produced [188ReO4]- (literal)
Abstract
  • A novel procedure for the high-yield preparation of Re-188 radiopharmaceuticals containing a terminal Re(N) multiple bond is described. This method involves the reaction of [188ReO4]- with N-methyl S-methyl dithiocarbazate, as donor of nitrido nitrogen atoms, sodium oxalate and SnCl2 to afford a mixture of two intermediate compounds. When this mixture is reacted with the sodium salt of a dithiocarbamate ligand (L), the formation of the bis-substituted neutral complexes [188Re(N)(L)2] is easily obtained in high yield (95%). The complexes [188Re(N)(L)2] were characterised by chromatographic methods and by comparison with the corresponding complexes prepared at macroscopic level starting from a non-radioactive rhenium precursor. Biodistribution studies were carried out in rats. Results showed that the complexes [188Re(N)(L)2] exhibited the same biological behaviour of the analogous Tc-99m complexes reported previously. The easy application of the new synthetic procedure indicates that it could be conveniently employed for preparing a large class of new Re-188 complexes having potential utilisation in Nuclear Medicine as therapeutic agents (literal)
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