http://www.cnr.it/ontology/cnr/individuo/prodotto/ID182522

Myocardial scarring by delayed enhancement cardiovascular magnetic resonance in thalassaemia major (Articolo in rivista)

Type

Prodotto della ricerca (Classe)
Articolo in rivista (Classe)

Label

Myocardial scarring by delayed enhancement cardiovascular magnetic resonance in thalassaemia major (Articolo in rivista) (literal)

Anno

2009-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1136/hrt.2008.156497 (literal)

Alternative label

A Pepe 1; V Positano 1; M Capra 2; A Maggio 3; C L Pinto 4; A Spasiano 5; G Forni 6; G Derchi 7; B Favilli 1; G Rossi 8; E Cracolici 9; M Midiri 9; M Lombardi 1 (2009)
Myocardial scarring by delayed enhancement cardiovascular magnetic resonance in thalassaemia major
in Heart (Lond., 1996); BMJ Publishing Group (British Medical Journals), London (Regno Unito)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

A Pepe 1; V Positano 1; M Capra 2; A Maggio 3; C L Pinto 4; A Spasiano 5; G Forni 6; G Derchi 7; B Favilli 1; G Rossi 8; E Cracolici 9; M Midiri 9; M Lombardi 1 (literal)

Pagina inizio

1688 (literal)

Pagina fine

1693 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

95 (literal)

Rivista

Heart (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

6 (literal)

Note

ubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

1 MRI Laboratory, Institute of Clinical Physiology, ''G Monasterio Foundation''/CNR, Pisa, Italy; 2 Pediatria per le Emopatie Ereditarie, G Di Cristina Hospital ARNAS, Palermo, Italy; 3 Ematologia II con Talassemia, ''V Cervello'' Hospital, Palermo, Italy; 4 Pediatria II per le Emopatie Ereditarie, Villa Sofia- CTO Hospital, Palermo, Italy; 5 Centro per la Cura delle Microcitemie, Cardarelli Hospital, Napoli, Italy; 6 Centro Microcitemia ed Anemie Congenite, Galliera Hospital, Genova, Italy; 7 Struttura Complessa di Cardiologia, Galliera Hospital, Genova, Italy; 8 Epidemiology and Biostatistics Unit, Institute of Clinical Physiology, CNR, Pisa, Italy; 9 Department of Radiology, University of Palermo, Palermo, Italy (literal)

Titolo

Myocardial scarring by delayed enhancement cardiovascular magnetic resonance in thalassaemia major (literal)

Abstract

Background: Cardiovascular magnetic resonance (CMR) by delayed enhancement (DE) enables visualisation of myocardial scarring, but no dedicated studies are available in thalassaemia major. Objective: To investigate the prevalence, extent, clinical and instrumental correlates of myocardial fibrosis or necrosis by DE CMR in patients with thalassaemia major. Patients: 115 Patients with thalassaemia major consecutively examined at an MRI laboratory. Methods: DE images were acquired to quantify myocardial scarring. Myocardial iron overload was determined by multislice multiecho T2*. Cine images were obtained to evaluate biventricular function. Results: DE areas were present in 28/115 patients (24%). The mean (SD) extent of DE was 3.9 (2.4)%. In 26 patients the location of fibrosis was not specific and patchy distribution was prevalent. Two patients showed transmural DE following coronary distribution. The DE group was significantly older than the no-DE group (31 (7.7) years vs 26 (7.7) years, p=0.004). No significant relation with heart T2* values and biventricular function was found. A significant correlation was found between the presence of DE and changes in ECG (ECG abnormal in the DE group 22/28 patients and in the no-DE group 30/87 patients; x2=14.9; p,0.001). Conclusions: In patients with thalassaemia the significant presence of myocardial fibrosis/necrosis seems to be a time dependent process correlating with cardiovascular risk factors and cardiac complications. Levels of HCV antibodies are significantly higher in the serum of patients with thalassaemia with myocardial fibrosis/necrosis. ECG changes showed a good accuracy in predicting myocardial scarring. (literal)

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