Structural Elucidation of a Novel B. cenocepacia ET-12 Lipooligosaccharide Isolated from a Cystic Fibrosis Patient after Lung Transplantation (Articolo in rivista)

Type
Label
  • Structural Elucidation of a Novel B. cenocepacia ET-12 Lipooligosaccharide Isolated from a Cystic Fibrosis Patient after Lung Transplantation (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Alternative label
  • T.Ieranò, A.Silipo, L.Sturiale, D.Garozzo, P.Corris, J.Perry, R.Lanzetta, M.Parrilli, A.De Soyza, A.Molinaro (2010)
    Structural Elucidation of a Novel B. cenocepacia ET-12 Lipooligosaccharide Isolated from a Cystic Fibrosis Patient after Lung Transplantation
    in European journal of organic chemistry (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • T.Ieranò, A.Silipo, L.Sturiale, D.Garozzo, P.Corris, J.Perry, R.Lanzetta, M.Parrilli, A.De Soyza, A.Molinaro (literal)
Pagina inizio
  • 1299 (literal)
Pagina fine
  • 1306 (literal)
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  • 2010 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
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  • Dipartimento di Chimica Organica e Biochimica, Università degli Studi di Napoli “Federico II” Via Cinthia 4, 80126 Napoli, Italy CNR-ICTP Catania, Via Gaifami 18, 95126 Catania, Italy Newcastle University, Institute of Cellular Medicine, The Medical School, Newcastle, NE2 4HH, UK Department of Medical Microbiology, The Freeman Hospital,Newcastle upon Tyne Hospitals Trust, Newcastle, NE7 7DN, UK (literal)
Titolo
  • Structural Elucidation of a Novel B. cenocepacia ET-12 Lipooligosaccharide Isolated from a Cystic Fibrosis Patient after Lung Transplantation (literal)
Abstract
  • In this work, we carried out the elucidation of a novel lipooligosaccharide (LOS) from a clinical strain of the most virulent strain of the Burkholderia cepacia complex, which was of B. cenocepacia ET-12 epidemic strain lineage. The strain was isolated from a cystic fibrosis patient who had successfully undergone lung transplantation. This molecule presents some specific chemical differences when compared to the LOS reported so far from other B. cenocepacia ET-12 clones. The new endotoxin was also tested as a cytokine enhancer on human myelomonocytic U937 cells. Lipopolysaccharides are the main virulence factors of Gram-negative bacteria, and since they are exposed to the extracellular space, they are deeply involved in bacterial adaptation to the host environment. The characterisation of structural motifs present in these molecules is essential to the comprehension of the persistence/survival mechanisms and inflammatory potential of these bacteria. (literal)
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