First structural characterization of Burkholderia vietnamiensis lipooligosaccharide from cystic fibrosis-associated lung transplantation strains (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• First structural characterization of Burkholderia vietnamiensis lipooligosaccharide from cystic fibrosis-associated lung transplantation strains (Articolo in rivista) (literal)

Anno

• 2009-01-01T00:00:00+01:00 (literal)

Alternative label

• T.Ieranò, A.Silipo, L.Sturiale, D.Garozzo, C.Bryant, R.Lanzetta, M.Parrilli, C.Aldridge,F.K.Gould, P.A.Corris, C.M.Anjam Khan, A.De Soyza, A.Molinaro (2009)
  First structural characterization of Burkholderia vietnamiensis lipooligosaccharide from cystic fibrosis-associated lung transplantation strains
  in Glycobiology (Oxf.)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• T.Ieranò, A.Silipo, L.Sturiale, D.Garozzo, C.Bryant, R.Lanzetta, M.Parrilli, C.Aldridge,F.K.Gould, P.A.Corris, C.M.Anjam Khan, A.De Soyza, A.Molinaro (literal)

Pagina inizio

• 1214 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 19 (literal)

Rivista

• Glycobiology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• ImpactFactor=3,886 (literal)

Note

• ISI Web of Science (WOS) (literal)

Titolo

• First structural characterization of Burkholderia vietnamiensis lipooligosaccharide from cystic fibrosis-associated lung transplantation strains (literal)

Abstract

• This is the first structural elucidation of the lipooligosaccharide (LOS) endotoxin isolated from Burkholderia vietnamiensis, a clinically important member of Burkholderia cepacia complex, a group of over 10 opportunistic species that are highly problematic in cystic fibrosis. We have characterized a novel LOS structure extracted from two clonal strains of B. vietnamiensis isolated from a cystic fibrosis patient who underwent lung transplantation. Strains were selected from the pretransplantation and post-transplantation periods and endotoxin was extracted. Subsequent analysis interestingly revealed identical oligosaccharidic sequences, but variation in lipid A moieties. Further, both LOS fractions were tested for their immunostimulatory activity on human myelomonocytic U937 cells and for signaling on an HEK293 cell line stably expressing both TLR 4 and MD-2. We observed an increase in lipid A acylation and a resultant increase in biological activity in bio-reporter assays of TNF-a secretion in the post-transplantation strain. (literal)

Prodotto di

• Glicomica e Proteomica per la ricerca di biomarcatori per la diagnosi e la terapia di patologie congenite, tumorali e infiammatorie. (PM.P06.013.001) (Modulo)
• Istituto di chimica e tecnologia dei polimeri (ICTP) (Istituto)

Autore CNR

• DOMENICO GAROZZO (Unità di personale interno)
• LUISELLA STURIALE (Persona)

Incoming links:

Autore CNR di

• DOMENICO GAROZZO (Unità di personale interno)
• LUISELLA STURIALE (Persona)

Prodotto

• Istituto di chimica e tecnologia dei polimeri (ICTP) (Istituto)
• Glicomica e Proteomica per la ricerca di biomarcatori per la diagnosi e la terapia di patologie congenite, tumorali e infiammatorie. (PM.P06.013.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Glycobiology (Rivista)