Severe Mechanical Dyssynchrony Causes Regional Hibernation-Like Changes in Pigs With Nonischemic Heart Failure (Articolo in rivista)

Type
Label
  • Severe Mechanical Dyssynchrony Causes Regional Hibernation-Like Changes in Pigs With Nonischemic Heart Failure (Articolo in rivista) (literal)
Anno
  • 2009-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.cardfail.2009.06.436 (literal)
Alternative label
  • Lionetti, V; Aquaro, G.D; Simioniuc, A; Di Cristofano, C; Forini, F; Cecchetti, F; Campan, M; De Marchi, D; Bernini, F; Grana, M; Nannipieri, M; Mancini, M; Lombardi, M; Recchia, F.A; Pingitore, A. (2009)
    Severe Mechanical Dyssynchrony Causes Regional Hibernation-Like Changes in Pigs With Nonischemic Heart Failure
    in Journal of cardiac failure (Online)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Lionetti, V; Aquaro, G.D; Simioniuc, A; Di Cristofano, C; Forini, F; Cecchetti, F; Campan, M; De Marchi, D; Bernini, F; Grana, M; Nannipieri, M; Mancini, M; Lombardi, M; Recchia, F.A; Pingitore, A. (literal)
Pagina inizio
  • 920 (literal)
Pagina fine
  • 928 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 15 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 10 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Sector of Medicine, Scuola Superiore Sant'Anna, Pisa, Italy National Institute of Biostructures and Biosystems, Bologna, Italy Institute of Clinical Physiology, CNR, Pisa, Italy Fondazione G. Monasterio, Pisa, Italy Department of Physiology, New York Medical College, Valhalla, 10595, United States Department of Internal Medicine, University of Pisa, Italy Unit of Anesthesiology and Intensive Care Medicine, Department of General Surgery, Vascular Surgery and Transplants, Cisanello Hospital, Pisa, Italy (literal)
Titolo
  • Severe Mechanical Dyssynchrony Causes Regional Hibernation-Like Changes in Pigs With Nonischemic Heart Failure (literal)
Abstract
  • Background: Sustained left ventricular (LV) dyssynchrony can lead to heart failure (HF) in the absence of coronary artery stenosis. We tested whether myocardial hibernation underlies the LV functional impairment caused by high-frequency pacing, an established model of nonischemic dilated cardiomyopathy. Methods and Results: Regional LV contractile and perfusion reserve were assessed by magnetic resonance imaging, respectively, as end-systolic wall thickening (LVESWT) and myocardial perfusion reserve index (MPRI) at rest and during low-dose dobutamine stress (LDDS, 10 ?g·kg·min intravenously for 10 minutes) in failing minipigs (n = 8). LV tissue was analyzed for glycogen deposits and other molecular hallmarks of hibernation. LDDS caused a marked increase in LVESWT (27 ± 2.98 vs. 7.15 ± 3 %, P < .05) and MPRI (2.1 ± 0.5 vs. 1.3 ± 0.3 P < .05) in the region that was activated first (pacing site) compared with the opposite region. Myocardial glycogen content was markedly increased in the pacing site (P < .05 vs. opposite region). In addition, gene expression of glycogen phosphorylase was reduced in pacing site compared with opposite regions (0.71 ± 0.1 vs. 1.03 ± 0.3, P < .05), whereas that of hexokinase type II was globally reduced by 83%. Conclusions: The combination of high heart rate and sustained dyssynchronous LV contraction causes asymmetrical myocardial hibernation, in absence of coronary artery stenosis. © 2009 Elsevier Inc. All rights reserved. (literal)
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