Relationship between periventricular and deep white matter lesions and depressive symptoms in older people. The LADIS Study. (Articolo in rivista)

Type
Label
  • Relationship between periventricular and deep white matter lesions and depressive symptoms in older people. The LADIS Study. (Articolo in rivista) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1002/gps.1596 (literal)
Alternative label
  • Krishnan MS; O'Brien JT; Firbank MJ; Pantoni L; Carlucci G; Erkinjuntti T; Wallin A; Wahlund LO; Scheltens P; van Straaten EC; Inzitari D; LADIS Group. (2006)
    Relationship between periventricular and deep white matter lesions and depressive symptoms in older people. The LADIS Study.
    in International journal of geriatric psychiatry
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Krishnan MS; O'Brien JT; Firbank MJ; Pantoni L; Carlucci G; Erkinjuntti T; Wallin A; Wahlund LO; Scheltens P; van Straaten EC; Inzitari D; LADIS Group. (literal)
Pagina inizio
  • 983 (literal)
Pagina fine
  • 989 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 21 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 7 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 10 (literal)
Note
  • Pubme (literal)
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Institute for Ageing and Health, University of Newcastle upon Tyne, UK Department of Neurological and Psychiatric Sciences, University of Florence, Italy Memory Research Unit, Department of Neurology, University of Helsinki, Finland Institute of Clinical Neuroscience, Go¨teborg University, Sweden Karolinska University Hospital, Huddinge, Sweden Alzheimer Center/ Dept Neurology VU University Hospital, Amsterdam, The Netherlands (literal)
Titolo
  • Relationship between periventricular and deep white matter lesions and depressive symptoms in older people. The LADIS Study. (literal)
Abstract
  • Background Both types of cerebral white matter hyperintensities, periventricular (PVL) and deep white matter lesions (DWML) have been previously associated with the development of depression in older subjects. However, it remains controversial as to whether PVL, DWML, or both are most strongly associated with depression and this was the aim of the current study. Methods In a pan-European multicentre study of 626 older subjects, we examined the relationship between PVL and DWML, depressive symptoms (GDS quintile), cognitive status (MMSE), hypertension and history of stroke. Results In univariate analysis we found that depressive symptoms as assessed by GDS were associated with both types of white matter lesions (Spearman rho = 0.12 p = 0.002 for DWML and rho = 0.09 p = 0.01 for PVL). Using ordinal logistic regression analysis the total DWML score (p = 0.041), rather than PVL (p = 0.9) was found to predict GDS scores. Conclusions DWML, but not PVL, were most strongly associated with depressive symptoms in this sample. As DWML (unlike PVL) are associated with vascular ischaemic damage, our findings are consistent with the 'vascular depression' hypothesis. Longitudinal studies are needed to clarify the time course of these relationships, in particular, whether modifying DWML alters the natural history of depression. (literal)
Prodotto di
Autore CNR
Insieme di parole chiave

Incoming links:


Prodotto
Autore CNR di
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
Insieme di parole chiave di
data.CNR.it