Vascular factors as predictors of polyneuropathy in a non-diabetic cohort of Italian elderly: the Italian longitudinal study on aging (ILSA) (Abstract in rivista)

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  • Vascular factors as predictors of polyneuropathy in a non-diabetic cohort of Italian elderly: the Italian longitudinal study on aging (ILSA) (Abstract in rivista) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1111/j.1468-1331.2008.02284.x (literal)
Alternative label
  • Baldereschi, M; Inzitari, M; Di Carlo, A; Scafato, E.; Inzitari, D. (2008)
    Vascular factors as predictors of polyneuropathy in a non-diabetic cohort of Italian elderly: the Italian longitudinal study on aging (ILSA)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Baldereschi, M; Inzitari, M; Di Carlo, A; Scafato, E.; Inzitari, D. (literal)
Pagina inizio
  • 15 (literal)
Pagina fine
  • 15 (literal)
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  • http://onlinelibrary.wiley.com (literal)
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  • 55 (literal)
Rivista
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  • 1 (literal)
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  • 3 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Univ Florence, Unit Gerontol & Geriatr, Florence, Italy I Italian Natl Res Council, Florence, Italy Ist Super Sanita, I-00161 Rome, Italy Univ Florence, Dept Neurol Sci, Florence, Italy (literal)
Titolo
  • Vascular factors as predictors of polyneuropathy in a non-diabetic cohort of Italian elderly: the Italian longitudinal study on aging (ILSA) (literal)
Abstract
  • Background and aims: Chronic polyneuropathy is a common diagnosis with an estimated prevalence of 7% in the elderly population, and it is a major predictor of poor motor function. Despite intensive investigation, 10-40% of patients with polyneuropathy referred to specialist centres, lack a causative diagnosis. We prospectively examined whether vascular factors are related to an increased incidence of Chronic Idiopathic Distal Symmetric Neuropathy (CI-DSN). Methods: The study population comprised 5,632 individuals of the ILSA. Potential effect of vascular factors was estimated by regressing CI-DSN on the occurrence of several vascular factors in a subcohort of 2,512 non-diabetic individuals.Multivariate relative risks of CI-DSN were estimated by Cox proportional hazards model. RESULTS. After 3.8 years of follow-up, we documented 51 incident CI-DSN cases.At univariate analyses, age, comorbidity, waist circumference, leg length, peripheral artery disease (PAD), and coronary hearth disease proved to significantly increased the risk of developing CI-DSN. Entering these significant covariates into a Cox regression model, only age (RR=1.08; 95%CI, 1.02 to 1.14), leg length (RR=1.05; 95%CI, 1.01 to 1.1), and PAD (RR=2.75; 95%CI, 1.15 to 6.56) proved significant predictors of CI-DSN. Conclusions: The presence at baseline of PAD is associated with a two-fold increase in the risk of developing CI-DSN. Our data from a population-based perspective strongly support the evidence that the incidence of polyneuropathy in non-diabetic individuals is associated with potentially modifiable vascular factors (literal)
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