The severity of growth hormone deficiency correlates with the severity of cardiac impairment in 100 adult patients with hypopituitarism: An observational, case-control study (Articolo in rivista)

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  • The severity of growth hormone deficiency correlates with the severity of cardiac impairment in 100 adult patients with hypopituitarism: An observational, case-control study (Articolo in rivista) (literal)
Anno
  • 2004-01-01T00:00:00+01:00 (literal)
Alternative label
  • Colao A; Di Somma C; Cuocolo A; Filippella M; Rota F; Acampa W; Savastano S; Salvatore M; Lombardi G (2004)
    The severity of growth hormone deficiency correlates with the severity of cardiac impairment in 100 adult patients with hypopituitarism: An observational, case-control study
    in The Journal of clinical endocrinology and metabolism
    (literal)
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  • Colao A; Di Somma C; Cuocolo A; Filippella M; Rota F; Acampa W; Savastano S; Salvatore M; Lombardi G (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1. Univ Naples Federico II, Dept Mol & Clin Endicrionol & Oncol, I-80131 Naples, Italy 2. Univ Naples Federico II, Dept Biomorphol & Funct Sci, I-80131 Naples, Italy 3. Univ Naples Federico II, Nucl Med Ctr, Natl Council Res, I-80131 Naples, Italy (literal)
Titolo
  • The severity of growth hormone deficiency correlates with the severity of cardiac impairment in 100 adult patients with hypopituitarism: An observational, case-control study (literal)
Abstract
  • In 100 patients with hypopituitarism and 80 sex- and age-matched healthy subjects, we correlated the severity of cardiac impairment to the severity of GH deficiency (GHD). By the GH peak after arginine plus GHRH test ( normal > 16.5 mug/liter), the patients were classified as severe GHD ( n = 56), partial GHD ( n = 27), and non-GHD ( n = 17). Compared with controls, decreased left ventricular ejection fraction at rest was found only in severe GHD patients (55.0 +/- 8.8 vs. 63.4 +/- 4.5%, P< 0.001); decreased left ventricular ejection fraction response on effort in severe ( - 4.6 +/- 17.4 vs. 15.2 +/- 9.1%, P < 0.001) and partial GHD patients (3.6 +/- 6.6 vs. 14.6 +/- 8.3%, P < 0.001); decreased diastolic filling at rest in severe (2.53 +/- 0.68 vs. 3.01 +/- 0.48 end-diastolic volume per second, P < 0.001) and partial GHD (2.61 +/- 0.45 vs. 2.89 +/- 0.54 end-diastolic volume per second, P = 0.004) patients; and decreased exercise duration and capacity in all the patient groups. A normal systolic performance on effort was found in 21.4% of severe GHD, 55.6% of partial GHD, all non-GHD, and 93.7% of controls. A normal diastolic filling at rest was found in 57.1% of severe GHD, 74.1% of partial GHD, 76.5% of non-GHD, and 90% of controls. In conclusion, cardiac performance is correlated with the GH status because significant impairment was found in patients with severe and partial GHD but not in non-GHD hypopituitary patients. (literal)
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