Engineered bone from bone marrow stromal cells: a structural study by an advanced x-ray microdiffraction technique (Articolo in rivista)

Type
Label
  • Engineered bone from bone marrow stromal cells: a structural study by an advanced x-ray microdiffraction technique (Articolo in rivista) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1088/0031-9155/51/6/N02 (literal)
Alternative label
  • A Cedola; M Mastrogiacomo; M Burghammer; V Komlev; P Giannoni; A Favia; R Cancedda; F Rustichelli;S Lagomarsino; (2006)
    Engineered bone from bone marrow stromal cells: a structural study by an advanced x-ray microdiffraction technique
    in Physics in medicine and biology (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • A Cedola; M Mastrogiacomo; M Burghammer; V Komlev; P Giannoni; A Favia; R Cancedda; F Rustichelli;S Lagomarsino; (literal)
Pagina inizio
  • N109 (literal)
Pagina fine
  • N116 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 51 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 6 (literal)
Note
  • Scopu (literal)
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1- Istituto di Fotonica e Nanotecnologie-CNR, V Cineto Romano 42, 00156 Roma, Italy 2- INFM, Department of Sciences Applied to Complex Systems, Polytechnic University of Marche, Via Ranieri 65, I60131 Ancona, Italy 3- Dipartimento di Oncologia, Biologia e Genetica, Universita' di Genova, Istituto Nazionale per la Ricerca sul Cancro-Genova, Largo R. Benzi 10, 16132 Genova, Italy 4- ESRF, BP 220, F-38043 Grenoble Cedex, France 5- Institute for Physical Chemistry of Ceramics, Russian Academy of Science, Ozernaya 48, 119361 Moscow, Russia 6- Biorigen Srl, Via Peschiera 16, 16122 Genova, Italy 7- Dipartimento di Anatomia Umana e Istologia, Universit`a degli Studi di Bari, P.le Giulio Cesare Policlinico, 70122 Bari, Italy (literal)
Titolo
  • Engineered bone from bone marrow stromal cells: a structural study by an advanced x-ray microdiffraction technique (literal)
Abstract
  • The mechanism of mineralized matrix deposition was studied in a tissue engineering approach in which bone tissue is formed when porous ceramic constructs are loaded with bone marrowstromal cells and implanted in vivo. We investigated the local interaction between themineral crystals of the engineered bone and the biomaterial by means of microdiffraction, using a set-up based on an x-ray waveguide. We demonstrated that the newly formed bone is well organized inside the scaffold pore, following the growth model of natural bone. Combiningwide angle (WAXS) and small angle (SAXS) x-ray scattering with high spatial resolution, we were able to determine the orientation of the crystallographic c-axis inside the bone crystals, and the orientation of the mineral crystals and collagen micro-fibrils with respect to the scaffold. In this work we analysed six samples and for each of them two pores were studied in detail. Similar results were obtained in all cases but we report here only the most significant sample. (literal)
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