Role of electrostatics in the thermal stability of ubiquitin - A combined DSC and MM study (Articolo in rivista)

Type
Label
  • Role of electrostatics in the thermal stability of ubiquitin - A combined DSC and MM study (Articolo in rivista) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1007/s10973-005-7467-0 (literal)
Alternative label
  • M. F. M. Sciacca1, D. Milardi2, M. Pappalardo1, C. La Rosa1 and D. M. Grasso1* (2006)
    Role of electrostatics in the thermal stability of ubiquitin - A combined DSC and MM study
    in Journal of thermal analysis and calorimetry (Online)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • M. F. M. Sciacca1, D. Milardi2, M. Pappalardo1, C. La Rosa1 and D. M. Grasso1* (literal)
Pagina inizio
  • 303 (literal)
Pagina fine
  • 314 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 86 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1Dipartimento di Scienze Chimiche, Universit? di Catania, Viale Andrea Doria 6, 95125 Catania, Italy 2Istituto CNR di Biostrutture e Bioimmagini-Sezione di Catania, Viale Andrea Doria 6, 95125 Catania, Italy (literal)
Titolo
  • Role of electrostatics in the thermal stability of ubiquitin - A combined DSC and MM study (literal)
Abstract
  • The failure of the ubiquitin-proteasome system is involved in many diseases. Here, in order to assess the pH-induced changes in the physico-chemical properties of ubiquitin, DSC measurements have been carried out at 2.5 < pH < 7. Parallel 'in silico' pH titrations, suggest that there is a direct relationship between the calorimetric data and the electrostatic properties of ubiquitin. It is suggested that these pH-induced changes in the properties of ubiquitin may play a role in determining its ability to properly conjugate with its physiological targets. (literal)
Prodotto di
Autore CNR
Insieme di parole chiave

Incoming links:


Autore CNR di
Prodotto
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
Insieme di parole chiave di
data.CNR.it