Morphology and metabolism of hepatocytes cultured in Petri dishes on films and in non-woven fabrics of hyaluronic acid esters (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Morphology and metabolism of hepatocytes cultured in Petri dishes on films and in non-woven fabrics of hyaluronic acid esters (Articolo in rivista) (literal)

Anno

• 2001-01-01T00:00:00+01:00 (literal)

Alternative label

• G. Catapano, L. De Bartolo, V. Vico, L. Ambrosio (2001)
  Morphology and metabolism of hepatocytes cultured in Petri dishes on films and in non-woven fabrics of hyaluronic acid esters
  in Biomaterials
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• G. Catapano, L. De Bartolo, V. Vico, L. Ambrosio (literal)

Pagina inizio

• 659 (literal)

Pagina fine

• 665 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 22 (literal)

Rivista

• Biomaterials (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Department of Chemical and Materials Engineering, University of Calabria, via P. Bucci cubo 17/C, I-87030 Rende (CS), Italy Research Institute on Membranes and Modelling of Chemical Reactors, IRMERC-CNR, c/o Department of Chemical and Materials Engineering, University of Calabria, via P. Bucci cubo 17/C, I-87030 Rende (CS), Italy Institute of Composite Materials Technology, CNR, Piazzale Tecchio 80, I-80125 Napoli, Italy (literal)

Titolo

• Morphology and metabolism of hepatocytes cultured in Petri dishes on films and in non-woven fabrics of hyaluronic acid esters (literal)

Abstract

• Polymers of hyaluronic acid (Hyal) esters exhibit good tissue compatibility and are available in various geometrical con\"gurations. These properties can be exploited for the design of innovative bioarti\"cial liver support devices (BALSDs) using primary hepatocytes. In this paper, we report a preliminary investigation of the polymer feasibility of the ethyl and the benzyl Hyal ester in the form of \"lms and non-woven fabrics for the in vitro culture of primary rat hepatocytes. Cell function was evaluated daily in Petri dishes with respect to the rate of ammonia elimination (AER) and urea synthesis (USR). Cells cultured in non-woven fabrics of the ethyl ester of Hyal (HYAFF7/8) exhibited an initial AER about 32% lower and synthesised urea 33% faster than that of cells on collagen \"lms. After a week in culture, cells on collagen \"lms retained only a minor fraction of their initial rates. Cells cultured in non-woven fabrics of HYAFF7/8 retained about 62 and 44% of their initial AER and USR, respectively, and exhibited an AER approximately equal to and a USR 3.6 times greater than those of cells adherent to collagen. These results suggest that non-woven fabrics of HYAFF7/8 are promising substrata for hepatocyte culture in BALSDs. (literal)

Prodotto di

• Membrane in organi artificiali (PM.P02.008.001) (Modulo)
• Institute on membrane technology (ITM) (Istituto)

Autore CNR

• LUIGI AMBROSIO (Unità di personale interno)
• LOREDANA DE BARTOLO (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "Morphology and metabolism of hepatocytes cultured in Petri dishes on films and in non-woven fabrics of hyaluronic acid esters" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute on membrane technology (ITM) (Istituto)
• Membrane in organi artificiali (PM.P02.008.001) (Modulo)

Autore CNR di

• LOREDANA DE BARTOLO (Unità di personale interno)
• LUIGI AMBROSIO (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Biomaterials (Rivista)

Insieme di parole chiave di

• Parole chiave di "Morphology and metabolism of hepatocytes cultured in Petri dishes on films and in non-woven fabrics of hyaluronic acid esters" (Insieme di parole chiave)