Eight year-cumulative incidence of parkinsonism (PK) and Parkinson's disease (PD). The Italian Longitudinal Study on Aging (ILSA) (Abstract/Comunicazione in rivista)

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Label
  • Eight year-cumulative incidence of parkinsonism (PK) and Parkinson's disease (PD). The Italian Longitudinal Study on Aging (ILSA) (Abstract/Comunicazione in rivista) (literal)
Anno
  • 2009-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1111/j.1468-1331.2009.02820. (literal)
Alternative label
  • Baldereschi, M; Di Carlo, A; Bovis, F; Inzitari, D for the ILSA Working Group (2009)
    Eight year-cumulative incidence of parkinsonism (PK) and Parkinson's disease (PD). The Italian Longitudinal Study on Aging (ILSA)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Baldereschi, M; Di Carlo, A; Bovis, F; Inzitari, D for the ILSA Working Group (literal)
Pagina inizio
  • 31 (literal)
Pagina fine
  • 31 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://onlinelibrary.wiley.com (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 16 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 1 (literal)
Note
  • Comunicazione (literal)
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Univ Florence, Dept Neurol Sci, I-50121 Florence, Italy (literal)
Titolo
  • Eight year-cumulative incidence of parkinsonism (PK) and Parkinson's disease (PD). The Italian Longitudinal Study on Aging (ILSA) (literal)
Abstract
  • Eight year-cumulative incidence of parkinsonism (PK) and Parkinson's disease (PD). The Italian Longitudinal Study on Aging (ILSA) M. Baldereschi1, A. Di Carlo1, F. Bovis2, D. Inzitari2, ILSA Working Group - Italian Longitudinal Study on Aging, Florence, Italy 1Institute of Neurosciences, Italian National Research Council, 2Dept. Neurological Sciences, University of Florence, Italy Background and aims: To investigate the incidence of PK and PD in the Italian elderly. Data on PD incidence are scarce and often based on few cases: questions of both a possible decline in the oldest ages and a possible male preponderance remain controversial. Materials: From population registries of 8 municipalities, 5632 individuals were random selected and equally allocated by gender and 5-year age-group (from 65 to 84 years of age). Methods: The cohort was surveyed three times, in 1992 (baseline), in 1995-96 (first follow-up) and in 2000 (second follow-up). Cases were identified with a two-phase procedure: direct screening of all the sampled individuals, and clinical confirmation of those who screened positive. Results: The PK-free cohort of 4341 individuals (lost to follow-up 36%) was followed for a median duration of 6.5 years (SD 2.96) yielding 26,928 person-years available for the analyses. We identified 167 PK and 103 (61.8%) PD incident cases. Rates for PK increase with age (ranging from 452 to 934 per 100,000 person-years), rates for PD plateaued after 75 years of age. By Cox analyses, for every year of age, the risk of developing PK was increased by 1.04 (95%CI, 1.01 to 1.07) and by 1.03 (95%CI, 1.00 to 1.06) for PD. Men outnumbered women in every age-group, but did not carry an increased risk either for PK or PD. Conclusions: PK and PD are common conditions among the elderly and their incidence keeps increasing with age, showing no decline in the oldest age-groups and no significant male preponderance (literal)
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