http://www.cnr.it/ontology/cnr/individuo/prodotto/ID178028

Metabolic syndrome and the risk of vascular dementia: the Italian Longitudinal Study on Ageing (Articolo in rivista)

Type

Articolo in rivista (Classe)
Prodotto della ricerca (Classe)

Label

Metabolic syndrome and the risk of vascular dementia: the Italian Longitudinal Study on Ageing (Articolo in rivista) (literal)

Anno

2010-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1136/jnnp.2009.181743 (literal)

Alternative label

Solfrizzi, V; Scafato, E; Capurso, C; D'Introno, A; Colacicco, AM; Frisardi, V; Vendemiale, G; Baldereschi, M; Crepaldi, G; Di Carlo, A; Galluzzo, L; Gandin, C; Inzitari, D; Maggi, S; Capurso, A; Panza, F . (2010)
Metabolic syndrome and the risk of vascular dementia: the Italian Longitudinal Study on Ageing
in Journal of neurology, neurosurgery and psychiatry
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Solfrizzi, V; Scafato, E; Capurso, C; D'Introno, A; Colacicco, AM; Frisardi, V; Vendemiale, G; Baldereschi, M; Crepaldi, G; Di Carlo, A; Galluzzo, L; Gandin, C; Inzitari, D; Maggi, S; Capurso, A; Panza, F . (literal)

Pagina inizio

433 (literal)

Pagina fine

440 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

http://jnnp.bmj.com/content/81/4/433.full.html (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

81 (literal)

Rivista

Journal of neurology, neurosurgery and psychiatry (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

8 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

4 (literal)

Note

ubMe (literal)
ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

Univ Bari, Dept Geriatr, Ctr Ageing Brain, Memory Unit, I-70124 Bari, Italy Ist Super Sanita, Ctr Epidemiol Surveillance & Hlth Promot CNESPS, Populat Hlth & Hlth determinants Unit, Natl Ctr Epidemiol, I-00161 Rome, Italy Univ Foggia, Dept Geriatr, Foggia, Italy IRCSS Casa Sollievo Sofferenza San Giovanni Roton, Internal Med Unit, Foggia, Italy CNR, Italian Natl Res Council, Inst Neurosci, Florence, Italy 6. CNR, Italian Natl Res Council, Ageing Sect, Padua, Italy 7. Univ Florence, Dept Neurol & Psychiat Sci, Florence, Italy (literal)

Titolo

Metabolic syndrome and the risk of vascular dementia: the Italian Longitudinal Study on Ageing (literal)

Abstract

OBJECTIVE: The authors investigated the relationship of metabolic syndrome (MetS) and its individual components with incident dementia in a prospective population-based study with a 3.5-year follow-up. METHODS: A total of 2097 participants from a sample of 5632 subjects (65-84 years old) from the Italian Longitudinal Study on Ageing were evaluated. MetS was defined according to the Third Adults Treatment Panel of the National Cholesterol Education Program criteria. Dementia, Alzheimer disease (AD) and vascular dementia (VaD) were classified using current published criteria. RESULTS: MetS subjects (N=918) compared with those without MetS (N=1179) had an increased risk for VaD (1.63% vs 0.85%, adjusted hazard ratio (HR) 3.71, 95% CI 1.40 to 9.83). After excluding 338 subjects with baseline undernutrition, MetS subjects compared with those without MetS had an elevated risk of VaD (adjusted HR, 3.82; 95% CI 1.32 to 11.06). Moreover, those with MetS and high inflammation had a still further higher risk of VaD (multivariate adjusted HR, 9.55; 95% CI 1.17 to 78.17) compared with those without MetS and high inflammation. On the other hand, those with MetS and low inflammation compared with those without MetS and low inflammation did not exhibit a significant increased risk of VaD (adjusted HR, 3.31, 95% CI 0.91 to 12.14). Finally, a synergistic MetS effect versus its individual component effects was verified on the risk of VaD. CONCLUSION: In our population, MetS subjects had an elevated risk of VaD that increased after excluding patients with baseline undernutrition and selecting MetS subjects with high inflammation. (literal)

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