Metabolic syndrome and the risk of vascular dementia: the Italian Longitudinal Study on Ageing (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Metabolic syndrome and the risk of vascular dementia: the Italian Longitudinal Study on Ageing (Articolo in rivista) (literal)

Anno

• 2010-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1136/jnnp.2009.181743 (literal)

Alternative label

• Vincenzo Solfrizzi; Emanuele Scafato; Cristiano Capurso; Alessia D'Introno; Anna Maria Colacicco; Vincenza Frisardi; Gianluigi Vendemiale;Marzia Baldereschi; Gaetano Crepaldi; Antonio Di Carlo; Lucia Galluzzo; Claudia Gandin; Domenico Inzitari; Stefania Maggi; Antonio Capurso; Francesco Panza; for the Italian Longitudinal Study on Ageing Working Group* (2010)
  Metabolic syndrome and the risk of vascular dementia: the Italian Longitudinal Study on Ageing
  in Journal of neurology, neurosurgery and psychiatry
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Vincenzo Solfrizzi; Emanuele Scafato; Cristiano Capurso; Alessia D'Introno; Anna Maria Colacicco; Vincenza Frisardi; Gianluigi Vendemiale;Marzia Baldereschi; Gaetano Crepaldi; Antonio Di Carlo; Lucia Galluzzo; Claudia Gandin; Domenico Inzitari; Stefania Maggi; Antonio Capurso; Francesco Panza; for the Italian Longitudinal Study on Ageing Working Group* (literal)

Pagina inizio

• 433 (literal)

Pagina fine

• 440 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.jnnp.bmj.com (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 81 (literal)

Rivista

• Journal of neurology, neurosurgery and psychiatry (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 8 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 4 (literal)

Note

• PubMe (literal)
• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Department of Geriatrics, Center for Ageing Brain,Memory Unit, University of Bari,Bari, Italy; Population Health and Health Determinants Unit, National Centre for Epidemiology, Surveillance and Health Promotion (CNESPS), Istituto Superiore di Sanità (ISS), Rome, Italy; Department of Geriatrics, University of Foggia, Foggia, Italy; Internal Medicine Unit, IRCSS Casa Sollievo dalla Sofferenza, San Giovanni Rotondo, Foggia,Italy; Institute of Neuroscience, Italian National Research Council (CNR), Florence, Italy; Italian National Research Council (CNR), Ageing Section, Padua, Italy; Department of Neurological and Psychiatric Sciences, University of Firenze, Florence, Italy; (literal)

Titolo

• Metabolic syndrome and the risk of vascular dementia: the Italian Longitudinal Study on Ageing (literal)

Abstract

• OBJECTIVE: The authors investigated the relationship of metabolic syndrome (MetS) and its individual components with incident dementia in a prospective population-based study with a 3.5-year follow-up. METHODS: A total of 2097 participants from a sample of 5632 subjects (65-84 years old) from the Italian Longitudinal Study on Ageing were evaluated. MetS was defined according to the Third Adults Treatment Panel of the National Cholesterol Education Program criteria. Dementia, Alzheimer disease (AD) and vascular dementia (VaD) were classified using current published criteria. RESULTS: MetS subjects (N=918) compared with those without MetS (N=1179) had an increased risk for VaD (1.63% vs 0.85%, adjusted hazard ratio (HR) 3.71, 95% CI 1.40 to 9.83). After excluding 338 subjects with baseline undernutrition, MetS subjects compared with those without MetS had an elevated risk of VaD (adjusted HR, 3.82; 95% CI 1.32 to 11.06). Moreover, those with MetS and high inflammation had a still further higher risk of VaD (multivariate adjusted HR, 9.55; 95% CI 1.17 to 78.17) compared with those without MetS and high inflammation. On the other hand, those with MetS and low inflammation compared with those without MetS and low inflammation did not exhibit a significant increased risk of VaD (adjusted HR, 3.31, 95% CI 0.91 to 12.14). Finally, a synergistic MetS effect versus its individual component effects was verified on the risk of VaD. CONCLUSION: In our population, MetS subjects had an elevated risk of VaD that increased after excluding patients with baseline undernutrition and selecting MetS subjects with high inflammation. (literal)

Prodotto di

• Istituto di neuroscienze (IN) (Istituto)
• Patologie e invecchiamento del Sistema Nervoso Centrale (ME.P02.006.002) (Modulo)

Autore CNR

• STEFANIA MAGGI (Unità di personale interno)
• MARZIA BALDERESCHI (Unità di personale interno)
• ANTONIO SALVATORE DI CARLO (Persona)

Insieme di parole chiave

• Keywords of "Metabolic syndrome and the risk of vascular dementia: the Italian Longitudinal Study on Ageing" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• ANTONIO SALVATORE DI CARLO (Persona)
• STEFANIA MAGGI (Unità di personale interno)
• MARZIA BALDERESCHI (Unità di personale interno)

Prodotto

• Istituto di neuroscienze (IN) (Istituto)
• Patologie e invecchiamento del Sistema Nervoso Centrale (ME.P02.006.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of neurology, neurosurgery and psychiatry (Rivista)

Insieme di parole chiave di

• Keywords of "Metabolic syndrome and the risk of vascular dementia: the Italian Longitudinal Study on Ageing" (Insieme di parole chiave)