Determination of quercetin and resveratrol in whole blood - implications for bioavailability studies. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Determination of quercetin and resveratrol in whole blood - implications for bioavailability studies. (Articolo in rivista) (literal)

Anno

• 2010-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.3390/molecules15096570 (literal)

Alternative label

• Lucia Biasutto; Ester Marotta; Spiridione Garbisa; Mario Zoratti; Cristina Paradisi (2010)
  Determination of quercetin and resveratrol in whole blood - implications for bioavailability studies.
  in Molecules (Basel, Online)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Lucia Biasutto; Ester Marotta; Spiridione Garbisa; Mario Zoratti; Cristina Paradisi (literal)

Pagina inizio

• 6570 (literal)

Pagina fine

• 6579 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.mdpi.com/1420-3049/15/9/6570/ (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 15 (literal)

Rivista

• Molecules (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 10 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 9 (literal)

Note

• ISI Web of Science (WOS) (literal)
• PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Lucia Biasutto; Spiridione Garbisa; Mario Zoratti: Dip. Scienze Biomediche Sperimentali, Università di Padova. Ester Marotta; Cristina Paradisi: Dip. di Scienze Chimiche, Università di Padova. Mario Zoratti: IN - Padova. (literal)

Titolo

• Determination of quercetin and resveratrol in whole blood - implications for bioavailability studies. (literal)

Abstract

• Resveratrol (trans-3,4',5-trihydroxystilbene) and quercetin (3,3',4',5,7-pentahydroxyflavone) are two naturally occurring polyphenols with the potential to exert beneficial health effects. Since their low bioavailability is a major obstacle to biomedical applications, efforts are being made to improve their absorption and slow down phase II metabolism. An accurate evaluation of the corresponding levels in the bloodstream is important to assess delivery strategies, as well as to verify claims of efficacy based on in vitro results. In the present work we have optimized a simple method ensuring complete stabilization and extraction of resveratrol and quercetin from whole blood. The suitability of different protocols was evaluated by measuring the recovery of polyphenol and internal standard from spiked blood samples via HPLC/UV analysis. The optimized procedure ensured a satisfactory recovery of both internal standards and compounds. Comparing plasma and whole blood, up to 76% of the analyte, being associated with the cellular fraction, was unaccounted for when examining only plasma. This indicates the importance of analysing whole blood rather than plasma to avoid underestimating polyphenol absorption in bioavailability studies. (literal)

Prodotto di

• Istituto di neuroscienze (IN) (Istituto)

Autore CNR

• LUCIA BIASUTTO (Unità di personale interno)
• MARIO ZORATTI (Persona)

Insieme di parole chiave

• Parole chiave di "Determination of quercetin and resveratrol in whole blood - implications for bioavailability studies." (Insieme di parole chiave)

Incoming links:

Autore CNR di

• MARIO ZORATTI (Persona)
• LUCIA BIASUTTO (Unità di personale interno)

Prodotto

• Istituto di neuroscienze (IN) (Istituto)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Molecules (Rivista)

Insieme di parole chiave di

• Parole chiave di "Determination of quercetin and resveratrol in whole blood - implications for bioavailability studies." (Insieme di parole chiave)