http://www.cnr.it/ontology/cnr/individuo/prodotto/ID176722

Cardiovascular Suite(FMD Studio+Carotid Studio) (Software)

Type

Software (Classe)
Prodotto della ricerca (Classe)

Label

Cardiovascular Suite(FMD Studio+Carotid Studio) (Software) (literal)

Anno

2010-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1161/CIRCULATIONAHA.110.941203 (literal)

Alternative label

Favilla Riccardo (2010)
Cardiovascular Suite(FMD Studio+Carotid Studio)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Favilla Riccardo (literal)

Pagina inizio

488 (literal)

Pagina fine

494 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

Il software è attualmente commercializzato dalla società Quipu SRL (uno spin-off del CNR-Istituto di Fisiologia Clinica di Pisa) e può essere provato liberamente per un periodo di 15 giorni (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

http://www.quipu.eu/ (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#titoloVolume

Circulation (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

2010 (literal)

Rivista

Circulation (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

122 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

CNR-IFC, Pisa (literal)

Titolo

Cardiovascular Suite(FMD Studio+Carotid Studio) (literal)

Descrizione sintetica

Cardiovascular Suite è un software che permette la valutazione non-invasiva di alcuni indicatori precoci di rischio cardiovascolare. Il prodotto, attualmente, è composto da due moduli, denominati FMD Studio e Carotid Studio, che rendono possibile la valutazione real-time di: -Flow Mediated Dilation dell'arteria brachiale (FMD Studio) -proprietà strutturali e funzionali dell'arteria carotidea (Carotid Studio) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autoriVolume

Pierre-Yves Jayet;Stefano F. Rimoldi; Thomas Stuber; Carlos Salinas Salmòn; Damian Hutter; Emrush Rexhaj; Sébastien Thalmann; Marcos Schwab; Pierre Turini; Céline Sartori-Cucchia; Pascal Nicod; Mercedes Villena; Yves Allemann; Urs Scherrer;Claudio Sartori (literal)

Abstract

Background--Adverse events in utero may predispose to cardiovascular disease in adulthood. The underlying mechanisms are unknown. During preeclampsia, vasculotoxic factors are released into the maternal circulation by the diseased placenta. We speculated that these factors pass the placental barrier and leave a defect in the circulation of the offspring that predisposes to a pathological response later in life. The hypoxia associated with high-altitude exposure is expected to facilitate the detection of this problem. Methods and Results--We assessed pulmonary artery pressure (by Doppler echocardiography) and flow-mediated dilation of the brachial artery in 48 offspring of women with preeclampsia and 90 offspring of women with normal pregnancies born and permanently living at the same high-altitude location (3600 m). Pulmonary artery pressure was roughly 30% higher (mean±SD, 32.1±5.6 versus 25.3±4.7 mm Hg; P<0.001) and flow-mediated dilation was 30% smaller (6.3±1.2% versus 8.3±1.4%; P<0.0001) in offspring of mothers with preeclampsia than in control subjects. A strong inverse relationship existed between flow-mediated dilation and pulmonary artery pressure (r=-0.61, P<0.001). The vascular dysfunction was related to preeclampsia itself because siblings of offspring of mothers with preeclampsia who were born after a normal pregnancy had normal vascular function. Augmented oxidative stress may represent an underlying mechanism because thiobarbituric acid-reactive substances plasma concentration was increased in offspring of mothers with preeclampsia. Conclusions--Preeclampsia leaves a persistent defect in the systemic and the pulmonary circulation of the offspring. This defect predisposes to exaggerated hypoxic pulmonary hypertension already during childhood and may contribute to premature cardiovascular disease in the systemic circulation later in life (literal)

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