http://www.cnr.it/ontology/cnr/individuo/prodotto/ID17663
Functional diversity of dystroglycan. (Articolo in rivista)
- Type
- Label
- Functional diversity of dystroglycan. (Articolo in rivista) (literal)
- Anno
- 2009-01-01T00:00:00+01:00 (literal)
- Alternative label
Bozzi M. a, Morlacchi S. b, Bigotti M.G. c, Sciandra F. d, Brancaccio A. d (2009)
Functional diversity of dystroglycan.
in Matrix biology (Print)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Bozzi M. a, Morlacchi S. b, Bigotti M.G. c, Sciandra F. d, Brancaccio A. d (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Note
- Scopu (literal)
- ISI Web of Science (WOS) (literal)
- PubMe (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- a Istituto di Biochimica e Biochimica Clinica, Università Cattolica del Sacro Cuore, Roma, Italy
b Dipartimento di Biologia Animale ed Ecologia Marina, Università degli Studi di Messina, Italy
c Department of Biochemistry, School of Medical Sciences, Bristol University, Bristol, UK
d Istituto di Chimica del Riconoscimento Molecolare (CNR) c/o Istituto di Biochimica e Biochimica Clinica, Università Cattolica del Sacro Cuore, Roma, Italy (literal)
- Titolo
- Functional diversity of dystroglycan. (literal)
- Abstract
- During the last 15 years, following its identification and first detailed molecular characterization, the
dystroglycan (DG) complex has taken centre stage in biology and biomedicine. Functions in different cells
and tissues have been identified for this complex, ranging from its typical role in skeletal muscle as a
sarcolemmal stabilizer, highlighted by the recently identified \"secondary dystroglycanopathies\", to a variety
of very diverse functions including embryogenesis, cancer progression, virus particle entry and cell signalling.
Such functional promiscuity can be in part explained when considering the multiple domain organization of
the two DG subunits, the extracellular alpha-DG and the transmembrane beta-DG, that has been largely scrutinized,
but only in part unraveled, exploiting a variety of recombinant and transgenic approaches. Herein, while
rapidly recapitulating some of the functions that nowadays can be assigned safely to each DG domain, we
also try to envisage a sort of worry list featuring and dwelling on some of the most compelling \"mysteries\"
that should be solved to finally understand DG's functional diversity. (literal)
- Prodotto di
- Autore CNR
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