Haemoglobin polymorphisms affect the oxygen-binding properties in Atlantic cod populations (Articolo in rivista)

Type
Label
  • Haemoglobin polymorphisms affect the oxygen-binding properties in Atlantic cod populations (Articolo in rivista) (literal)
Anno
  • 2009-01-01T00:00:00+01:00 (literal)
Alternative label
  • Øivind Andersen; Ola Frang Wetten; Maria Cristina De Rosa; Carl Andre; Cristiana Carelli Alinovi; Mauro Colafranceschi; Ole Brix; Alfredo Colosimo (2009)
    Haemoglobin polymorphisms affect the oxygen-binding properties in Atlantic cod populations
    in Proceedings - Royal Society. Biological sciences (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Øivind Andersen; Ola Frang Wetten; Maria Cristina De Rosa; Carl Andre; Cristiana Carelli Alinovi; Mauro Colafranceschi; Ole Brix; Alfredo Colosimo (literal)
Pagina inizio
  • 833 (literal)
Pagina fine
  • 841 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 276 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Nofima, PO Box 5010, 1430 Aas, Norway; CIGENE--Centre of Integrative Genetics, 1430 Aas, Norway; Department of Natural Science and Technology, Hedmark University College, 2318 Hamar, Norway; Department of Animal and Aquaculture Sciences, Norwegian University of Life Sciences, 1430 Aas, Norway; Institute of Chemistry of Molecular Recognition--CNR, 00168 Rome, Italy; Department of Marine Ecology-Tja¨rno¨, Go¨teborg University, 45296 Stro¨mstad, Sweden; Institute of Biochemistry and Clinical Biochemistry, Catholic University of Rome, 00168 Rome, Italy; Department of Human Physiology and Pharmacology, University of Rome 'La Sapienza', 00185 Rome, Italy; CISB Interdepartmental Centre, University of Rome 'La Sapienza', 00186 Rome, Italy; Department of Biology, University of Bergen, 5020 Bergen, Norway; The Michelsen Centre for Industrial Measurement Science and Technology, 5892 Bergen, Norway; (literal)
Titolo
  • Haemoglobin polymorphisms affect the oxygen-binding properties in Atlantic cod populations (literal)
Abstract
  • A major challenge in evolutionary biology is to identify the genes underlying adaptation. The oxygentransporting haemoglobins directly link external conditions with metabolic needs and therefore represent a unique system for studying environmental effects on molecular evolution. We have discovered two haemoglobin polymorphisms in Atlantic cod populations inhabiting varying temperature and oxygen regimes in the North Atlantic. Three-dimensional modelling of the tetrameric haemoglobin structure demonstrated that the two amino acid replacementsMet55beta1Val and Lys62beta1Ala are located at crucial positions of the alpha1beta1 subunit interface and haempocket, respectively. The replacements are proposed to affect the oxygen-binding properties by modifying the haemoglobin quaternary structure and electrostatic feature. Intriguingly, the same molecularmechanismfor facilitating oxygen binding is found in avian species adapted to high altitudes, illustrating convergent evolution in water- and air-breathing vertebrates to reduction in environmental oxygen availability. Cod populations inhabiting the cold Arctic waters and the low-oxygen Baltic Sea seem well adapted to these conditions by possessing the high oxygen affinity Val55-Ala62 haplotype, while the temperature-insensitive Met55-Lys62 haplotype predominates in the southern populations. The distinct distributions of the functionally different haemoglobin variants indicate that the present biogeography of this ecologically and economically important species might be seriously affected by global warming. (literal)
Prodotto di
Autore CNR

Incoming links:


Autore CNR di
Prodotto
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
data.CNR.it