Impurities of tazarotene: Isolation and structural characterisation (Articolo in rivista)

Type
Label
  • Impurities of tazarotene: Isolation and structural characterisation (Articolo in rivista) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.jpba.2007.11.004 (literal)
Alternative label
  • Brenna E., Frigoli S., Fronza G., Fuganti C., Serra S. (2008)
    Impurities of tazarotene: Isolation and structural characterisation
    in Journal of pharmaceutical and biomedical analysis (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Brenna E., Frigoli S., Fronza G., Fuganti C., Serra S. (literal)
Pagina inizio
  • 574 (literal)
Pagina fine
  • 576 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 46 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • CNR-ICRM Politecnico di Milano (literal)
Titolo
  • Impurities of tazarotene: Isolation and structural characterisation (literal)
Abstract
  • Two impurities showing structures 5 and 6 were isolated and characterised by means of NMR analysis, during the optimisation of a synthetic procedure to tazarotene. Impurity 5, i.e. ethyl 6-((4,4-dimethyl-4H-thiochromen-6-yl)ethynyl)nicotinate, was a by-product of the reduction of the intermediate sulfoxide 7 with PCl3. Impurity 6, i.e. 1,4-bis(4,4-dimethylthiochroman-6-yl)buta-1,3-diyne, was due to a side reaction of the Sonogashira coupling. (literal)
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