Synthesis, platelet adhesion and cytotoxicity studies of new glycerophosphoryl-containing polyurethanes (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Synthesis, platelet adhesion and cytotoxicity studies of new glycerophosphoryl-containing polyurethanes (Articolo in rivista) (literal)

Anno

• 2007-01-01T00:00:00+01:00 (literal)

Alternative label

• D'Arrigo P., Giordano C., Macchi P., Malpezzi L., Pedrocchi-Fantoni G., Servi S. (2007)
  Synthesis, platelet adhesion and cytotoxicity studies of new glycerophosphoryl-containing polyurethanes
  in The International Journal of Artificial Organs (Testo stamp.)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• D'Arrigo P., Giordano C., Macchi P., Malpezzi L., Pedrocchi-Fantoni G., Servi S. (literal)

Pagina inizio

• 133 (literal)

Pagina fine

• 143 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 30 (literal)

Rivista

• ?The ?International Journal of Artificial Organs (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 2 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• ICRM, CNR (literal)

Titolo

• Synthesis, platelet adhesion and cytotoxicity studies of new glycerophosphoryl-containing polyurethanes (literal)

Abstract

• In this work we synthesized new MD1-based poly(ether)urethanes (PEUs) with phospholipid-like residue as chain extender Polymers were prepared by a conventional two-step solution polymerization procedure using 4,4'-diphenylmethanediisocyanate (MDI) and poly(1,4-butanediol) with 1000 as molecular weight to form prepolymers which were successively polymerized with 1-glycerophosphorylcholine (1-GPC), 2-glycerophosphorylcholine (2-(GPC) or glycerophosphorylserine (GPS) as chain extenders. Two reference polymers bearing 1,4-butandiol (BD) have been also synthesized. The polymers obtained were characterized by Fourier transform infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR), differential scanning calorimetry DSC) and modulated scanning calorimetry (MDSC). The biocompatibility of synthesized segmented polyurethanes was then investigated by platelet-rich plasma contact studies and related scanning electron microscopy (SEM) photographs for blood compatibility and cytotoxicity assay (MTT test) on material elution to assess the effect of any toxic leachables on cellular viability. Three polymers among all have given very satisfactory results suggesting to investigate more deeply their possible use in biomedical devices. (literal)

Prodotto di

• Istituto di chimica del riconoscimento molecolare (ICRM) (Istituto)
• Applicazioni sintetiche della biocatalisi (PM.P03.009.002) (Modulo)

Autore CNR

• STEFANO SERVI (Unità di personale esterno)
• GIUSEPPE ANDREA PEDROCCHI FANTONI (Persona)

Incoming links:

Prodotto

• Istituto di chimica del riconoscimento molecolare (ICRM) (Istituto)
• Applicazioni sintetiche della biocatalisi (PM.P03.009.002) (Modulo)

Autore CNR di

• GIUSEPPE ANDREA PEDROCCHI FANTONI (Persona)
• STEFANO SERVI (Unità di personale esterno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• ?The ?International Journal of Artificial Organs (Rivista)