Interaction of nitric oxide with the activity of cytosolic NADH/cytochrome c electron transport system (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Interaction of nitric oxide with the activity of cytosolic NADH/cytochrome c electron transport system (Articolo in rivista) (literal)

Anno

• 2009-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.abb.2009.07.020 (literal)

Alternative label

• Marzulli, Domenico; Gorgoglione, Vincenza ; Palmitessa, Valeria; La Piana, Gianluigi; Lofrumento, Nicola Elio; Laraspata, Daniela (2009)
  Interaction of nitric oxide with the activity of cytosolic NADH/cytochrome c electron transport system
  in Archives of biochemistry and biophysics (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Marzulli, Domenico; Gorgoglione, Vincenza ; Palmitessa, Valeria; La Piana, Gianluigi; Lofrumento, Nicola Elio; Laraspata, Daniela (literal)

Pagina inizio

• 99 (literal)

Pagina fine

• 109 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 489 (literal)

Rivista

• Archives of biochemistry and biophysics (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 10 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1-2 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Department of Biochemistry and Molecular Biology, University of Bari Institute of Biomembranes and Bioenergetics (literal)

Titolo

• Interaction of nitric oxide with the activity of cytosolic NADH/cytochrome c electron transport system (literal)

Abstract

• Nitric oxide ({radical dot}NO) generated by the dissociation of S-nitrosoglutathione or added as gaseous solution, inhibits the oxidation of exogenous NADH supported by the activity of the cytosolic NADH/cyto-c electron transport pathway. The inhibition is immediate, very strong, higher at lower oxygen concentration, independent on the {radical dot}NO concentration and remains constant as long as {radical dot}NO is no more available and then is spontaneously removed. The data obtained, not in contrast with those reported with isolated cytochrome oxidase (Cox), strengthen a new concept: reduced cytochrome c (cyto-c) and {radical dot}NO behave as two substrates of Cox, which promotes their oxidation with molecular oxygen as a co-substrate. In the presence of {radical dot}NO, Cox exhibits the property of switching from cyto-c oxidase to {radical dot}NO oxidase activity. With an \"all or nothing\" process Cox becomes an efficient {radical dot}NO scavenger. The persistence of membrane potential, even in the presence of high inhibition of oxygen uptake, could be tentatively correlated to the protective effect of {radical dot}NO on the ischaemic-reperfusion injury (literal)

Prodotto di

• Sistemi boenergetici di membrana: meccanismi funzionali e fisiopatologia. (SV.P14.005.001) (Modulo)
• Istituto di biomembrane e bioenergetica (IBBE) (Istituto)

Autore CNR

• DOMENICO MARZULLI (Persona)

Insieme di parole chiave

• Parole chiave di "Interaction of nitric oxide with the activity of cytosolic NADH/cytochrome c electron transport system" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di biomembrane e bioenergetica (IBBE) (Istituto)
• Sistemi boenergetici di membrana: meccanismi funzionali e fisiopatologia. (SV.P14.005.001) (Modulo)

Autore CNR di

• DOMENICO MARZULLI (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Archives of biochemistry and biophysics (Rivista)

Insieme di parole chiave di

• Parole chiave di "Interaction of nitric oxide with the activity of cytosolic NADH/cytochrome c electron transport system" (Insieme di parole chiave)