Detection in human saliva of different statherin and P-B fragments and derivatives (Articolo in rivista)

Type
Label
  • Detection in human saliva of different statherin and P-B fragments and derivatives (Articolo in rivista) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
Alternative label
  • Inzitari R1; Cabras T2; Rossetti D.V1; Fanali C1; Vitali A3; Pellegrini M2; Paludetti G1; Manni A1; Giardina B2,3; Messana I2; Castagnola M1,3 (2006)
    Detection in human saliva of different statherin and P-B fragments and derivatives
    in Proteomics (Weinh., Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Inzitari R1; Cabras T2; Rossetti D.V1; Fanali C1; Vitali A3; Pellegrini M2; Paludetti G1; Manni A1; Giardina B2,3; Messana I2; Castagnola M1,3 (literal)
Pagina inizio
  • 6370 (literal)
Pagina fine
  • 6379 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 6 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1 Università Cattolica, Facoltà Medicina, Roma 2 Università Cagliari 3 ICRM CNR (literal)
Titolo
  • Detection in human saliva of different statherin and P-B fragments and derivatives (literal)
Abstract
  • Statherin is a multifunctional polypeptide specific of human saliva involved in oral calcium homeostasis, phosphate buffering and formation of protein networks. Salivary P-B peptide is usually included into the basic proline-rich protein family but it shows some similarities with statherin and its specific biological role is still undefined. In this study, various fragments and derivatives of statherin and P-B peptide were consistently detected by RP-HPLC ESI-IT MS in 23 samples of human saliva. They were: statherin mono- and non-phosphorylated, statherin Des-Phe(43) (statherin SV1), statherin Des-Thr(42),Phe(43), statherin Des-Asp(1), statherin Des(6-15) (statherin SV2), statherin Des(1-9), statherin Des(1-10), statherin Des(1-13) and P-B Des(1-5). Statherin SV3 (statherin Des(6-15), Phe(43)) was detected only in one sample. Identity of the fragments was confirmed either by MS/MS experiments or by enzymatic digestion or by Edman sequencing. Detection of the fragments suggests that statherin and P-B peptide are submitted to post-translational proteolytic cleavages that are common to other classes of salivary proteins (literal)
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