http://www.cnr.it/ontology/cnr/individuo/prodotto/ID17404
Novel highly potent, structurally simple gamma-trifluoromethyl gamma-sulfone hydroxamate inhibitor of stromelysin-1 (MMP-3) (Articolo in rivista)
- Type
- Label
- Novel highly potent, structurally simple gamma-trifluoromethyl gamma-sulfone hydroxamate inhibitor of stromelysin-1 (MMP-3) (Articolo in rivista) (literal)
- Anno
- 2005-01-01T00:00:00+01:00 (literal)
- Alternative label
Sani M., Candiani G., Pecker F., Malpezzi L., Zanda M. (2005)
Novel highly potent, structurally simple gamma-trifluoromethyl gamma-sulfone hydroxamate inhibitor of stromelysin-1 (MMP-3)
in Tetrahedron letters
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Sani M., Candiani G., Pecker F., Malpezzi L., Zanda M. (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Note
- ISI Web of Science (WOS) (literal)
- Titolo
- Novel highly potent, structurally simple gamma-trifluoromethyl gamma-sulfone hydroxamate inhibitor of stromelysin-1 (MMP-3) (literal)
- Abstract
- The gamma-trifluoromethyl gamma-sulfone hydroxamate 1 was synthesized both in racemic and enantiomerically pure forms by means of a thia-Michael reaction of p-methoxythiophenol on achiral and chiral 3,3,3-trifluorocrotonoyl Michael acceptors. The (R)-1 enantiomer was the most potent inhibitor of MMP-3 (stromelysin-1), showing an IC50 = 3.2 nM, as well as the most selective with respect to MMP-9 (65-fold). (c) 2005 Elsevier Ltd. All rights reserved. (literal)
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- Autore CNR
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