A practical and efficient process for the preparation of tazarotene (Articolo in rivista)

Type
Label
  • A practical and efficient process for the preparation of tazarotene (Articolo in rivista) (literal)
Anno
  • 2005-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1021/op050080x (literal)
Alternative label
  • Frigoli S., Fuganti C., Malpezzi L., Serra S. (2005)
    A practical and efficient process for the preparation of tazarotene
    in Organic process research & development
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Frigoli S., Fuganti C., Malpezzi L., Serra S. (literal)
Pagina inizio
  • 646 (literal)
Pagina fine
  • 650 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 9 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • CNR - ICRM Politecnico di Milano (literal)
Titolo
  • A practical and efficient process for the preparation of tazarotene (literal)
Abstract
  • We describe an efficient process for the preparation of tazarotene starting from 4,4-dimethyl-6-bromothiochromane S-oxide (9), 2-methyl-3-butyn-2-ol (10), and 6-chloronicotinic acid ethyl ester (8). Our synthetic pathway compares favorably over the previously reported procedures since tazarotene was prepared straightforwardly using cheap reagents and without the employment of hazardous organometallic compounds. The process is based on the use of sulfoxide 9 as key starting material. The C-15 framework of the target was built up by means of two different approaches based on a palladium-mediated coupling reaction. The molecular structure of compound has been confirmed by X-ray crystallography. (literal)
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Autore CNR

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