The immunomodulatory protein SV-IV protects serum-deprived cells against apoptosis but not against G0/G1 arrest: possible implications for the survival of implanting embryo (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• The immunomodulatory protein SV-IV protects serum-deprived cells against apoptosis but not against G0/G1 arrest: possible implications for the survival of implanting embryo (Articolo in rivista) (literal)

Anno

• 2007-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1002/jcp.21058 (literal)

Alternative label

• Morelli F.1; Peluso G.2; Petillo O.2; Giannattasio A.1; Filosa S.3; Motta C. M.3; Tammaro, S.3; Zatterale A.4; Calzone R.4; Budillon A.5; Cartenì M.6; De Maria S.6; Costanza M. R.6; Nigro A.6; Petrazzuolo M.6; Buommino E.1; Rizzo M.7; Capasso G.7; Baiano S.1; Moscatiello F.1; Ravagnan G.8; Fuggetta M. P.9; Tajana G.10; Stiuso P.11; Metafora B. M.1; Metafora V.1 and MetaforaS1. (2007)
  The immunomodulatory protein SV-IV protects serum-deprived cells against apoptosis but not against G0/G1 arrest: possible implications for the survival of implanting embryo
  in Journal of cellular physiology (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Morelli F.1; Peluso G.2; Petillo O.2; Giannattasio A.1; Filosa S.3; Motta C. M.3; Tammaro, S.3; Zatterale A.4; Calzone R.4; Budillon A.5; Cartenì M.6; De Maria S.6; Costanza M. R.6; Nigro A.6; Petrazzuolo M.6; Buommino E.1; Rizzo M.7; Capasso G.7; Baiano S.1; Moscatiello F.1; Ravagnan G.8; Fuggetta M. P.9; Tajana G.10; Stiuso P.11; Metafora B. M.1; Metafora V.1 and MetaforaS1. (literal)

Pagina inizio

• 610 (literal)

Pagina fine

• 625 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 212 (literal)

Rivista

• Journal of cellular physiology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 3 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto

• Pubblicazione (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1 Inst. of Genet. and Biophys. Adriano Buzzati-Traverso, CNR, Naples, Italy; 2 CNR, Inst. of Enzymology and Protein Biochem., Via P. Castellino 111, Naples, Italy; 3 Dep. of Evolut. and Comp. Biology, Univ. Federico II, Via Mezzocannone 8, Naples, Italy; 4 Osp. Elena d'Aosta, ASL Napoli 1, Dep. of Genet., Via Cagnazzi 29, Naples, Italy; 5 Dep. of Experim.Onc., Experim. Pharmacol. Unit, National Inst. of Tumours Fondazione G. Pascale, Via Mariano Semmola, Naples, Italy; 6 Department of Experimental Medicine, Medical School, II University of Naples, Via Costantinopoli 16, Naples, Italy; 7 Department of Nephrology and Research Center for Cardiovascular Diseases, Medical School, II University of Naples, Naples, Italy; 8 Department of Environmental Sciences, Ca` Foscari Venezia University, Calle Larga Santa Marta, Venice, Italy; 9 Institute of Neurobiology and Molecular Medicine (INMM, CNR), Area Ricerca Roma ''Tor Vergata'', I-00133 Rome, Italy; 10 Department of Pharmacological Sciences, University of Salerno, Fisciano, Salerno, Italy; 11 Department of Biochemistry and Biophysics, Medical School, II University of Naples, Via Costantinopoli 16, Naples, Italy; (literal)

Titolo

• The immunomodulatory protein SV-IV protects serum-deprived cells against apoptosis but not against G0/G1 arrest: possible implications for the survival of implanting embryo (literal)

Abstract

• Serum deprivation induced in human lymphoblastoid Raji cells oxidative stress-associated apoptotic death and G0/G1 cell cycle arrest. Addition into culture medium of the immunomodulatory protein Seminal vesicle protein 4 (SV-IV) protected these cells against apoptosis but not against cycle arrest. The antiapoptotic activity was related to: (1) decrease of endocellular reactive Oxygen species (ROS) (2) increase of mRNAs encoding anti-oxidant enzymes (catalase, G6PD) and antiapoptotic proteins (survivin, cox-1, Hsp70, c-Fos); (3) decrease of mRNAs encoding proapoptotic proteins (c-myc, Bax, caspase-3, Apaf-1). The biochemical changes underlaying these effects were probably induced by a protein tyrosine kinase (PTK) activity triggered by the binding of SV-IV to its putative plasma membrane receptors. The ineffectiveness of SV-IV to abrogate the cycle arrest was accounted for by its downregulating effects on D1,3/E G1-cyclins and CdK2/4 gene expression, ppRb/pRb ratio, and intracellular ROS concentration. In conclusion, these experiments: (1) prove that SV-IV acts as a cell survival factor; (2) suggest the involvement of a PTK in SV-IV signaling; (3) point to cell cycle-linked enzyme inhibition as responsible for cycle arrest; (4) provide a model to dissect the cycle arrest and apoptosis induced by serum withdrawal; (5) imply a possible role of SV-IV in the survival of hemiallogenic implanting embryos. (literal)

Prodotto di

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)
• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Institute of protein biochemistry (IBP) (Istituto)
• Immunofarmacologia di sostanze naturali e di sintesi nell’ambito della crescita neoplastica in vivo ed in vitro. (ME.P03.006.002) (Modulo)
• DR. PELUSO: Nanotecnologie applicate alla terapia genica e cellulare (PM.P02.014.001) (Modulo)

Autore CNR

• MARIA PIA FUGGETTA (Unità di personale interno)
• FRANCESCO MORELLI (Persona)
• GIANFRANCO PELUSO (Persona)

Insieme di parole chiave

• Keywords of "The immunomodulatory protein SV-IV protects serum-deprived cells against apoptosis but not against G0/G1 arrest: possible implications for the survival of implanting embryo" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• MARIA PIA FUGGETTA (Unità di personale interno)
• GIANFRANCO PELUSO (Persona)
• FRANCESCO MORELLI (Persona)

Prodotto

• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Institute of protein biochemistry (IBP) (Istituto)
• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)
• Immunofarmacologia di sostanze naturali e di sintesi nell’ambito della crescita neoplastica in vivo ed in vitro. (ME.P03.006.002) (Modulo)
• DR. PELUSO: Nanotecnologie applicate alla terapia genica e cellulare (PM.P02.014.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of cellular physiology (Rivista)

Insieme di parole chiave di

• Keywords of "The immunomodulatory protein SV-IV protects serum-deprived cells against apoptosis but not against G0/G1 arrest: possible implications for the survival of implanting embryo" (Insieme di parole chiave)