The dystroglycan complex: From biology to cancer (Articolo in rivista)

Type
Label
  • The dystroglycan complex: From biology to cancer (Articolo in rivista) (literal)
Anno
  • 2005-01-01T00:00:00+01:00 (literal)
Alternative label
  • 1Sgambato A.; 2Brancaccio A. (2005)
    The dystroglycan complex: From biology to cancer
    in Journal of cellular physiology (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • 1Sgambato A.; 2Brancaccio A. (literal)
Pagina inizio
  • 163 (literal)
Pagina fine
  • 169 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 205 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
  • PubMe (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1Centro di Ricerche Oncologiche ''Giovanni XXIII'', Istituto di Patologia Generale, Catholic University, Rome, Italy 2Istituto di Chimica del Riconoscimento Molecolare-Sezione di Roma (CNR) C/o Istituto di Biochimica e Biochimica Clinica, Catholic University, Rome, Italy (literal)
Titolo
  • The dystroglycan complex: From biology to cancer (literal)
Abstract
  • Dystroglycan VG), a non-integrin adhesion molecule, is a pivotal component of the dystrophin-glycoprotein complex, that is expressed in skeletal muscle and in a wide variety of tissues at the interface between the basement membrane (BM) and the cell membrane. DG has been mainly studied for its role in skeletal muscle cell stability and its alterations in muscular diseases, such as dystrophies. However, accumulating evidence have implicated DG in a variety of other biological functions, such as maturation of post-synaptic elements in the central and peripheral nervous system, early morphogenesis, and infective pathogens targeting. Moreover, DG has been reported to play a role in regulating cytoskeletal organization, cell polarization, and cell growth in epithelial cells. Recent studies also indicate that abnormalities in the expression of DG frequently occur in human cancers and may play a role in both the process of tumor progression and in the maintenance of the malignant phenotype. This paper reviews the available information on the biology of DG, the abnormalities found in human cancers, and the implications of these findings with respect to our understanding of cancer pathogenesis and to the development of novel strategies for a better management of cancer patients. (literal)
Prodotto di
Autore CNR

Incoming links:


Autore CNR di
Prodotto
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
data.CNR.it