Activated Akt as an indicator of prognosis in gastric cancer (Articolo in rivista)

Type
Label
  • Activated Akt as an indicator of prognosis in gastric cancer (Articolo in rivista) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Alternative label
  • Cinti C.; Vindigni C.; Zamparelli A.; La Sala D.; Epistolato M. C.; Marrelli D.; Cevenini G.; Tosi P. (2008)
    Activated Akt as an indicator of prognosis in gastric cancer
    in Virchows Archiv
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Cinti C.; Vindigni C.; Zamparelli A.; La Sala D.; Epistolato M. C.; Marrelli D.; Cevenini G.; Tosi P. (literal)
Pagina inizio
  • 449 (literal)
Pagina fine
  • 455 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 453 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • IFC-CNR Siena CNR-IFC, Siena, Dip. Patologia Umana e Oncologia Univ Siena, CNR-IGM, Bologna, Dip. Patologia umana e Oncologia Univ Siena, Dip. Chirurigia e Bioingegneria Univ. Siena, Dipt. Patologia Umana e Oncologia Univ Siena (literal)
Titolo
  • Activated Akt as an indicator of prognosis in gastric cancer (literal)
Abstract
  • The immunohistochemical expression of phosphorylated (activated) Akt (pAkt) in 50 advanced gastric carcinomas has been analyzed and the results correlated with age, sex, location in the stomach, histotype, stage, survival, mitotic and apoptotic index, some cell cycle regulators (cyclin D1, cyclin E, p34/cdc2, p27/kip1), and cell proliferation. There was a statistically significant direct correlation between pAkt expression (both cytoplasmatic and nuclear) and depth of infiltration of the tumor, number of infiltrated lymph nodes and p34/cdc2 expression, and between prevalently nuclear pAkt and cyclin D1 and cyclin E. Conversely, there was a significant inverse correlation between nuclear pAkt and apoptotic index and between cytoplasmatic and nuclear pAkt and patient survival. No correlation was found between pAkt and sex, age, tumor location, histotype, mitotic index, and cell proliferation. These findings suggest that pAkt may be considered an indicator of tumor progression and patient survival in gastric cancer (literal)
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