Variation of hemoglobin levels in normal Italian populations from genetic isolates (Articolo in rivista)

Type
Label
  • Variation of hemoglobin levels in normal Italian populations from genetic isolates (Articolo in rivista) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.3324/haematol.12915 (literal)
Alternative label
  • Sala C; Ciullo M; Lanzara C; Nutile T; Bione S; Massacane R; d'Adamo P; Gasparini P; Toniolo D; Camaschella C. (2008)
    Variation of hemoglobin levels in normal Italian populations from genetic isolates
    in Haematologica (Roma); Ferrata Storti Foundation, Pavia (Italia)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Sala C; Ciullo M; Lanzara C; Nutile T; Bione S; Massacane R; d'Adamo P; Gasparini P; Toniolo D; Camaschella C. (literal)
Pagina inizio
  • 1372 (literal)
Pagina fine
  • 1375 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.haematologica.org/content/93/9/1372.long (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 93 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 4 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 9 (literal)
Note
  • PubMe (literal)
  • ISI Web of Science (WOS) (literal)
  • Scopu (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • DIBIT-San Raffaele Scientific Institute and Vita e Salute University, Milano, Italy; Institute of Genetics and Biophysics “Adriano Buzzati-Traverso” CNR Naples, Italy; IRCCS Burlo Garofalo and University of Trieste, Italy; Laboratorio ASL 22 Novi Ligure, Italy. (literal)
Titolo
  • Variation of hemoglobin levels in normal Italian populations from genetic isolates (literal)
Abstract
  • Normal Hb levels vary greatly according to genetic and acquired factors. As a consequence there is no general agreement on the definition of anemia in terms of hemoglobin (Hb) levels. Here we compare the Hb levels of subjects recruited from normal genetically isolated Italian populations whose medical history, life style habits and results of laboratory tests are available. After the exclusion of pathological samples we analyzed the Hb levels of 3,849 subjects (1,661 males and 2,188 females) and evaluated the Hb heritability. Normal subjects of different age groups from a northern Italian isolate have significantly higher Hb levels when compared to matched subjects of southern Italian isolates. The estimated heritability of Hb levels ranges from 0.34 to 0.42 in the different isolates. Our study provides a dataset of Hb levels for normal subjects of different geographical origin and indicate that Hb levels are substantially influenced by heritable components. (literal)
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