The FoxO3/type 2 deiodinase pathway is required for normal mouse myogenesis and muscle regeneration (Articolo in rivista)

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  • The FoxO3/type 2 deiodinase pathway is required for normal mouse myogenesis and muscle regeneration (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1172/JCI43670 (literal)
Alternative label
  • Dentice M.; Marsili A.; Ambrosio R.; Guardiola O.; Sibilio A.; Paik J.H.; Minchiotti G.; DePinho R.A.; Fenzi G.; Larsen P.R.; Salvatore D. (2010)
    The FoxO3/type 2 deiodinase pathway is required for normal mouse myogenesis and muscle regeneration
    in The Journal of clinical investigation
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Dentice M.; Marsili A.; Ambrosio R.; Guardiola O.; Sibilio A.; Paik J.H.; Minchiotti G.; DePinho R.A.; Fenzi G.; Larsen P.R.; Salvatore D. (literal)
Pagina inizio
  • 4021 (literal)
Pagina fine
  • 4030 (literal)
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  • http://www.jci.org/articles/view/43670 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 120 (literal)
Rivista
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  • PMID: 20978344 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 11 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Department of Molecular and Clinical Endocrinology and Oncology, University of Naples \"Federico II,\" Naples, Italy. Thyroid Section, Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. IRCCS Fondazione SDN, Naples, Italy. Stem Cell Fate Laboratory, Institute of Genetics and Biophysics \"A. Buzzati-Traverso,\" CNR, Naples, Italy. Belfer Institute for Applied Cancer Science, Departments of Medical Oncology, Medicine and Genetics, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA. CEINGE-Biotecnologie Avanzate s.c. a r.l., Naples, Italy. (literal)
Titolo
  • The FoxO3/type 2 deiodinase pathway is required for normal mouse myogenesis and muscle regeneration (literal)
Abstract
  • The active thyroid hormone 3,5,3' triiodothyronine (T3) is a major regulator of skeletal muscle function. The deiodinase family of enzymes controls the tissue-specific activation and inactivation of the prohorrnone thyroxine (T4). Here we show that type 2 deiodinase (D2) is essential for normal mouse myogenesis and muscle regeneration. Indeed, D2-mediated increases in T3 were essential for the enhanced transcription of myogenic differentiation 1 (MyoD) and for execution of the myogenic program. Conversely, the expression of T3-dependent genes was reduced and after injury regeneration markedly delayed in muscles of mice null for the gene encoding D2 (Dio2), despite normal circulating T3 concentrations. Forkhead box 03 (Fox03) was identified as a key molecule inducing D2 expression and thereby increasing intracellular T3 production. Accordingly, Fox03-depleted primary myoblasts also had a differentiation deficit that could be rescued by high levels of T3. In conclusion, the Fox03/D2 pathway selectively enhances intracellular active thyroid hormone concentrations in muscle, providing a striking example of how a circulating hormone can be tissue-specifically activated to influence development locally. (literal)
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