Catecholaminergic phenotype of human Leydig cells. (Articolo in rivista)

Type
Label
  • Catecholaminergic phenotype of human Leydig cells. (Articolo in rivista) (literal)
Anno
  • 2004-01-01T00:00:00+01:00 (literal)
Alternative label
  • Romeo R, Pellitteri R, Russo A, Marcello MF. (2004)
    Catecholaminergic phenotype of human Leydig cells.
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Romeo R, Pellitteri R, Russo A, Marcello MF. (literal)
Pagina inizio
  • 45 (literal)
Pagina fine
  • 54 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 109 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • natomy, Diagnostic Pathology, Phorens Medicine, Hygiene and Public Health, Departments, University of Catania, Via S. Sofia, 87-95123 Catania.°Institute of Neurological Sciences, National Research Council, Section ofCatania, viale R. Margherita 6, 95123 Catania, Italy. (literal)
Titolo
  • Catecholaminergic phenotype of human Leydig cells. (literal)
Abstract
  • Catecholamines are neurotransmitters involved in the regulation of testicular function and they activate the Leydig cell receptors. To assess whether the two key-enzymes involved in the synthesis of catecholamines are present in human testis we examined the expression of Tirosine Hydroxylase (TH) and Dopamine-beta-Hydroxylase (DBH) antigens by immunoperoxidase and immunofluorescence techniques. Sections from testicular biopsies of adult and infant patients were processed by two antibodies. In all specimens Leydig cells stain positively. Differences in the staining positivity among single Leydig cells and among cell groups as well as among Leydig cells from different patients were noted. In some of the reactions a small number of Leydig cells was negative. Most of the immunoreactivity is evenly distributed within the cytoplasm of the Leydig cells. We suggest that the heterogeneous expression among Leydig cells could be correlated to their different metabolic activity. Our observations show a local intratesticular source of catecholamines which, in concert with nervous and blood-stream sources, could be involved in the spermatogenesis regulation. In particular, during psychogenic or somatic stress situations also the local catecholamine production by autocrine and/or paracrine mechanism could contribute to the high concentration of catecholamines and to suppression of the testicular functions. (literal)
Prodotto di
Autore CNR
Insieme di parole chiave

Incoming links:


Autore CNR di
Prodotto
Insieme di parole chiave di
data.CNR.it