Thyroid hormone and coronary artery disease: from clinical correlations to prognostic implications (Articolo in rivista)

Type
Label
  • Thyroid hormone and coronary artery disease: from clinical correlations to prognostic implications (Articolo in rivista) (literal)
Anno
  • 2009-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1002/clc.20574 (literal)
Alternative label
  • Coceani M.; Iervasi G.; Pingitore A.; Carpeggiani C.; L'Abbate A. (2009)
    Thyroid hormone and coronary artery disease: from clinical correlations to prognostic implications
    in Clinical cardiology (Mahwah N.J.)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Coceani M.; Iervasi G.; Pingitore A.; Carpeggiani C.; L'Abbate A. (literal)
Pagina inizio
  • 380 (literal)
Pagina fine
  • 385 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 32 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
  • In: Clinical Cardiology, vol. 32 (7) pp. 380 - 385. Wiley periodicals, INC, 2009. (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Fondazione CNR-Regione Toscana Gabriele Monasterio, Pisa, Italy; CNR Institute of Clinical Physiology, Pisa, Italy (literal)
Titolo
  • Thyroid hormone and coronary artery disease: from clinical correlations to prognostic implications (literal)
Abstract
  • Background: Overt thyroid dysfunction, hypothyroidism in particular, may lead to coronary artery disease (CAD). Whether more subtle anomalies of thyroid hormone metabolism influence the progression of CAD remains a matter of speculation. Hypothesis: The occurrence of CAD and long-term prognosis in patients without a history of either primary thyroid disease, myocardial infarction, or chronic heart failure is related to serum levels of biologically active free triiodothyronine (fT3). Methods: The cohort consisted of 1047 clinically and biochemically euthyroid patients (median age 65.6 y and 69% male) who underwent coronary angiography in our institute for suspected CAD. Results: Lower fT3 levels were predictive of both single-vessel (p = 0.012) and multivessel (p = 0.009) CAD. Through a multivariate logistic regression analysis, fT3 was still linked to the presence of CAD (hazard ratio [HR]: 0.48, 95% confidence interval [CI]: 0.34-0.68, p 0.001). After a mean follow-up of 31 months, the survival rate was95%and total mortality (log-rank 6.75, p (literal)
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