Altered expression of nerve growth factor and its receptors in the kidneys of diabetic rats (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Altered expression of nerve growth factor and its receptors in the kidneys of diabetic rats (Articolo in rivista) (literal)

Anno

• 2011-01-01T00:00:00+01:00 (literal)

Alternative label

• Aloe L., Rossi S., Manni L. (2011)
  Altered expression of nerve growth factor and its receptors in the kidneys of diabetic rats
  in JN. Journal of Nephrology (Milano, 1992)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Aloe L., Rossi S., Manni L. (literal)

Pagina inizio

• 798 (literal)

Pagina fine

• 805 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• doi: 10.5301/JN.2011.6418. 2011 Mar 4 [Epub ahead of print] (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 24 (literal)

Rivista

• JN. Journal of Nephrology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• (*) L'INMM è stato soppresso il 12/1/2011 con provvedimento prot. n. 0002122 ed è confluito nell'IBCN costituito il 21/12/2010 con provvedimento prot. n. 0091899. (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Istituto di Farmacologia traslazionale, CNR. Istituto di Biologia Cellulare e Neurobiologia, CNR. (literal)

Titolo

• Altered expression of nerve growth factor and its receptors in the kidneys of diabetic rats (literal)

Abstract

• Background: Type 1 diabetes (DB) is a multifactorial metabolic disorder characterized by loss of insulin-producing pancreatic ß-cells, and metabolic and functional deficits in a number of cells, including kidney cells. Nerve growth factor (NGF) is a signaling molecule that is up-regulated in cells affected by diabetes-linked disorders. However, whether DB alters the expression of NGF in the kidney is not known. Methods: DB was induced in adult male rats with a single injection of streptozotocin (STZ), and NGF protein levels were analyzed in a time-course study in serum and kidney. The expression of NGF receptors in the kidneys of healthy and DB rats was evaluated by immunohistochemistry. NGF levels as well as apoptotic features in the kidneys of healthy rats injected with purified NGF were also assessed. Results: This study revealed that DB elevates NGF levels in serum and NGF expression in the kidney and that subcutaneous administration of NGF causes a marked uptake of NGF in kidney cells. The elevated presence of NGF in kidney cells is not associated with proapoptotic factor expression. Conclusions: The present data suggest that NGF presence in the kidney might play a survival, and most probably protective, role in kidney cells. (literal)

Prodotto di

• ex ME.P02.010.001 / Patologie del S.N. e Fattori di Crescita (ME.P02.010.004) (Modulo)
• ex SV.P16.007.001 / Funzioni del S.N./Neurotrofine (SV.P16.007.004) (Modulo)

Autore CNR

• LUIGI ALOE (Unità di personale esterno)
• LUIGI MANNI (Unità di personale interno)

Incoming links:

Autore CNR di

• LUIGI MANNI (Unità di personale interno)
• LUIGI ALOE (Unità di personale esterno)

Prodotto

• ex ME.P02.010.001 / Patologie del S.N. e Fattori di Crescita (ME.P02.010.004) (Modulo)
• ex SV.P16.007.001 / Funzioni del S.N./Neurotrofine (SV.P16.007.004) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• JN. Journal of Nephrology (Rivista)