Caffeine enhances astroglia and microglia reactivity induced by 3,4-methylenedioxymethamphetamine ('Ecstasy') in mouse brain. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Caffeine enhances astroglia and microglia reactivity induced by 3,4-methylenedioxymethamphetamine ('Ecstasy') in mouse brain. (Articolo in rivista) (literal)

Anno

• 2010-01-01T00:00:00+01:00 (literal)

Alternative label

• Khairnar A., Plumitallo A., Frau L., Schintu N., Morelli M. (2010)
  Caffeine enhances astroglia and microglia reactivity induced by 3,4-methylenedioxymethamphetamine ('Ecstasy') in mouse brain.
  in Neurotoxicity resarch
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Khairnar A., Plumitallo A., Frau L., Schintu N., Morelli M. (literal)

Pagina inizio

• 435 (literal)

Pagina fine

• 439 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 17 (literal)

Rivista

• Neurotoxicity resarch (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• UNIVERSITA' DI CAGLIARI (literal)

Titolo

• Caffeine enhances astroglia and microglia reactivity induced by 3,4-methylenedioxymethamphetamine ('Ecstasy') in mouse brain. (literal)

Abstract

• Several reports suggest that 3,4-methylenedioxymethamphetamine (MDMA) induces neurotoxic effects and gliosis. Since recreational use of MDMA is often associated with caffeinated beverages, we investigated whether caffeine interferes with MDMA-induced astroglia and microglia activation, thus facilitating its neurotoxicity. MDMA (4 x 20 mg/kg) was acutely administered to mice alone or in combination with caffeine (10 mg/kg). CD11b and GFAP immunoreactivity were evaluated as markers of microglia and astroglia activation in the substantia nigra pars-compacta (SNc) and striatum. MDMA was associated with significantly higher CD11b and GFAP immunoreactivity in striatum, whereas only CD11b was significantly higher than vehicle in SNc. Caffeine potentiated the increase in CD11b and GFAP in the striatum but not in the SNc of MDMA-treated mice. The abuse of MDMA is a growing worldwide problem; the results of this study suggest that combination of MDMA plus caffeine by increasing glial activation might have harmful health consequences. (literal)

Prodotto di

• Istituto di neuroscienze (IN) (Istituto)
• Neurobiologia delle dipendenze (ME.P02.009.001) (Modulo)

Autore CNR

• ANNALISA PINNA (Unità di personale interno)
• MICAELA MORELLI (Persona)

Insieme di parole chiave

• Parole chiave di "Caffeine enhances astroglia and microglia reactivity induced by 3,4-methylenedioxymethamphetamine ('Ecstasy') in mouse brain." (Insieme di parole chiave)

Incoming links:

Autore CNR di

• ANNALISA PINNA (Unità di personale interno)
• MICAELA MORELLI (Persona)

Prodotto

• Istituto di neuroscienze (IN) (Istituto)
• Neurobiologia delle dipendenze (ME.P02.009.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Neurotoxicity resarch (Rivista)

Insieme di parole chiave di

• Parole chiave di "Caffeine enhances astroglia and microglia reactivity induced by 3,4-methylenedioxymethamphetamine ('Ecstasy') in mouse brain." (Insieme di parole chiave)