Coronary microcirculatory vasoconstriction is heterogeneously distrbuted in acutely ischemic myocardium (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Coronary microcirculatory vasoconstriction is heterogeneously distrbuted in acutely ischemic myocardium (Articolo in rivista) (literal)

Anno

• 2005-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1152/ajpheart.00870.2004 (literal)

Alternative label

• Gianmario Sambuceti; Mario Marzilli; Andrea Mari; Cecilia Marini; Mathis Schluter; Roberto Testa; Michaela Papini; Paolo Marraccini; Giuseppe Ciriello; Paolo Marzullo; and Antonio L'Abbate (2005)
  Coronary microcirculatory vasoconstriction is heterogeneously distrbuted in acutely ischemic myocardium
  in American journal of physiology. Heart and circulatory physiology
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Gianmario Sambuceti; Mario Marzilli; Andrea Mari; Cecilia Marini; Mathis Schluter; Roberto Testa; Michaela Papini; Paolo Marraccini; Giuseppe Ciriello; Paolo Marzullo; and Antonio L'Abbate (literal)

Pagina inizio

• H2298 (literal)

Pagina fine

• 2305 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://ajpheart.physiology.org/ (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 288 (literal)

Rivista

• American journal of physiology. Heart and circulatory physiology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• In: \"Am J Physiol Heart Circ Physiol\",288, 2005,5,H2298-H2305 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 8 (literal)

Note

• PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1Institute of Clinical Physiology, Italian National Research Council, Pisa; 2Institute of Systems Science and Biomedical Engineering, Padova; 3Ospedale Santa Maria Nuova, Firenze; and 4Scuola Superiore di Studi Universitari Sant'Anna, Pisa, Italy (literal)

Titolo

• Coronary microcirculatory vasoconstriction is heterogeneously distrbuted in acutely ischemic myocardium (literal)

Abstract

• The classical model of coronary physiology implies the presence of maximal microcirculatory vasodilation during myocardial ischemia. However, Doppler monitoring of coronary blood flow (CBF) documented severe microcirculatory vasoconstriction during pacing-induced ischemia in patients with coronary artery disease. This study investigates the mechanisms that underlie this paradoxical behavior in nine patients with stable angina and single-vessel coronary disease who were candidates for stenting. While transstenotic pressures were continuously monitored, input CBF (in ml/min) to the poststenotic myocardium was measured by Doppler catheter and angiographic cross-sectional area. Simultaneously, specific myocardial blood flow (MBF, in ml·min-1·g-1) was measured by 133Xe washout. Perfused tissue mass was calculated as CBF/MBF. Measurements were obtained at baseline, during pacing-induced ischemia, and after stenting. CBF and distal coronary pressure values were also measured during pacing with intracoronary adenosine administration. During pacing, CBF decreased to 64 ± 24% of baseline and increased to 265 ± 100% of ischemic flow after adenosine administration. In contrast, pacing increased MBF to 184 ± 66% of baseline, measured as a function of the increased rate-pressure product (r = 0.69; P < 0.05). Thus, during pacing, perfused myocardial mass drastically decreased from 30 ± 23 to 12 ± 11 g (P < 0.01). Distal coronary pressure remained stable during pacing but decreased after adenosine administration. Stenting increased perfused myocardial mass to 39 ± 23 g (P < 0.05 vs. baseline) as a function of the increase in distal coronary pressure (r = 0.71; P < 0.02). In conclusion, the vasoconstrictor response to pacing-induced ischemia is heterogeneously distributed and excludes a tissue fraction from perfusion. Within perfused tissue, the metabolic demand still controls the vasomotor tone. (literal)

Prodotto di

• Institute of biomedical engineering (ISIB) (Istituto)
• Metodi e modelli matematici per la ricerca clinica sul metabolismo, il diabete e sue complicanze (ME.P06.016.001) (Modulo)
• Istituto di fisiologia clinica (IFC) (Istituto)

Autore CNR

• ANDREA MARI (Unità di personale interno)
• PAOLO MARRACCINI (Persona)

Incoming links:

Prodotto

• Institute of biomedical engineering (ISIB) (Istituto)
• Istituto di fisiologia clinica (IFC) (Istituto)
• Metodi e modelli matematici per la ricerca clinica sul metabolismo, il diabete e sue complicanze (ME.P06.016.001) (Modulo)

Autore CNR di

• ANDREA MARI (Unità di personale interno)
• PAOLO MARRACCINI (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• American journal of physiology. Heart and circulatory physiology (Rivista)