http://www.cnr.it/ontology/cnr/individuo/prodotto/ID170971
Direct Evidence of the Amino Acid Side Chain and Backbone Contributions to Protein Anharmonicity (Articolo in rivista)
- Type
- Label
- Direct Evidence of the Amino Acid Side Chain and Backbone Contributions to Protein Anharmonicity (Articolo in rivista) (literal)
- Anno
- 2010-01-01T00:00:00+01:00 (literal)
- Alternative label
Schiro, Giorgio; Caronna, Chiara; Natali, Francesca; Cupane, Antonio (2010)
Direct Evidence of the Amino Acid Side Chain and Backbone Contributions to Protein Anharmonicity
in Journal of the American Chemical Society (Print)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Schiro, Giorgio; Caronna, Chiara; Natali, Francesca; Cupane, Antonio (literal)
- Pagina inizio
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- Rivista
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Department of Physical and Astronomical Sciences, UniVersity of Palermo, Via Archirafi 36,
I-90123 Palermo, Italy, European Synchrotron Radiation Facility, B.P. 220,
F-38043 Grenoble, France, and INFM-CNR OGG and CRS-SOFT, c/o ILL,
6 Rue Jules Horowitz, BP 156-38042 Grenoble, France (literal)
- Titolo
- Direct Evidence of the Amino Acid Side Chain and Backbone Contributions to Protein Anharmonicity (literal)
- Abstract
- Elastic incoherent neutron scattering has been used to study the temperature dependence of
the mean-square displacements of nonexchangeable hydrogen atoms in powders of a series of homomeric
polypeptides (polyglycine, polyalanine, polyphenylalanine and polyisoleucine) in comparison with myoglobin
at the same hydration level (h ) 0.2). The aim of the work was to measure the dynamic behavior of different
amino acid residues separately and assess the contribution of each type of side chain to the anharmonic
dynamics of proteins. The results provide direct experimental evidence that the first anharmonic activation,
at ~150 K, is largely due to methyl group rotations entering the time window of the spectrometer used;
however, contributions on the order of 10-20% from the motions of other groups (e.g., the phenolic ring
and the methylene groups) are present. Our data also indicate that the dynamical transition occurring at
~230 K can be attributed, at least at the hydration level investigated, mainly to motions involving backbone
fluctuations. (literal)
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