Assessing the molecular basis for rat-selective induction of the mitochondrial permeability transition by norbormide (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Assessing the molecular basis for rat-selective induction of the mitochondrial permeability transition by norbormide (Articolo in rivista) (literal)

Anno

• 2007-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.bbabio.2007.04.002 (literal)

Alternative label

• Zulian A; Petronilli V; Bova S; Dabbeni-Sala F; Cargnelli G; Cavalli M; Rennison D; Stäb J; Laita O; Lee DJ; Brimble MA; Hopkins B; Bernardi P; Ricchelli F (2007)
  Assessing the molecular basis for rat-selective induction of the mitochondrial permeability transition by norbormide
  in Biochimica et biophysica acta. Bioenergetics
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Zulian A; Petronilli V; Bova S; Dabbeni-Sala F; Cargnelli G; Cavalli M; Rennison D; Stäb J; Laita O; Lee DJ; Brimble MA; Hopkins B; Bernardi P; Ricchelli F (literal)

Pagina inizio

• 980 (literal)

Pagina fine

• 988 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 1767 (literal)

Rivista

• Biochimica et biophysica acta. Bioenergetics (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 7 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Rennison D, Brimble MA, Stab J, Laita O, Lee DJ, University of Auckland, Auckland, New Zealand; Bova S, Cavalli M, Zulian A, Dabbeni-Sala F, Cargnelli G, Bernardi P, University of Padova; Hopkins B, Landcare Research, Lincoln, New Zealand; Ricchelli F, Petronilli V, CNR (literal)

Titolo

• Assessing the molecular basis for rat-selective induction of the mitochondrial permeability transition by norbormide (literal)

Abstract

• It was recently demonstrated that the rat-selective toxicant norbormide also induces rat-selective opening of the permeability transition pore (PTP) in isolated mitochondria. Norbormide is a mixture of endo and exo stereoisomers; however, only the endo forms are lethal to rats. In the present study we tested both endo and exo isomers as well as neutral and cationic derivatives of norbormide to: (i) verify if the PTP-regulatory activity by norbormide is stereospecific; (ii) define the structural features of norbormide responsible for PTP-activation, (iii) elucidate the basis for the drug species-specificity. Our results show that: (i) norbormide isomers affect PTP in a rat-selective fashion; however, no relevant differences between lethal and non-lethal forms are observed suggesting that drug regulation of PTP-activity and lethality in rats are unrelated phenomena; (ii) a (phenylvinyl)pyridine moiety represents the key element conferring the PTP-activating effect; (iii) cationic derivatives of rat-active compounds accumulate in the matrix via the membrane potential and activate the PTP also in mouse and guinea pig mitochondria. These findings suggest that the norbormide-sensitive PTP-target is present in all species examined, and is presumably located on the matrix side. The species-selectivity may depend on the unique properties of a transport system allowing drug internalisation in rat mitochondria. (literal)

Prodotto di

• Neurobiologia e Neuropatologia (ME.P02.005.001) (Modulo)
• Neuroscienze (ME.P02.016.001) (Modulo)
• Istituto di neuroscienze (IN) (Istituto)

Autore CNR

• FERNANDA RICCHELLI (Unità di personale interno)
• PAOLO BERNARDI (Unità di personale esterno)
• VALERIA PETRONILLI (Unità di personale interno)

Insieme di parole chiave

• Keywords of "Assessing the molecular basis for rat-selective induction of the mitochondrial permeability transition by norbormide" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• VALERIA PETRONILLI (Unità di personale interno)
• FERNANDA RICCHELLI (Unità di personale interno)
• PAOLO BERNARDI (Unità di personale esterno)

Prodotto

• Istituto di neuroscienze (IN) (Istituto)
• Neuroscienze (ME.P02.016.001) (Modulo)
• Neurobiologia e Neuropatologia (ME.P02.005.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Biochimica et biophysica acta. Bioenergetics (Rivista)

Insieme di parole chiave di

• Keywords of "Assessing the molecular basis for rat-selective induction of the mitochondrial permeability transition by norbormide" (Insieme di parole chiave)