Generation and functional characterization of a BCL10-inhibitory peptide that represses NF-kappaB activation (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Generation and functional characterization of a BCL10-inhibitory peptide that represses NF-kappaB activation (Articolo in rivista) (literal)

Anno

• 2009-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1042/BJ20090055 (literal)

Alternative label

• Marasco D; Stilo R; Sandomenico A; Monti SM; Tizzano B; de Capua A; Varricchio E; Liguoro D; Zotti T; Formisano S; Ruvo M; Vito P (2009)
  Generation and functional characterization of a BCL10-inhibitory peptide that represses NF-kappaB activation
  in Biochemical journal (Lond., 1984)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Marasco D; Stilo R; Sandomenico A; Monti SM; Tizzano B; de Capua A; Varricchio E; Liguoro D; Zotti T; Formisano S; Ruvo M; Vito P (literal)

Pagina inizio

• 553 (literal)

Pagina fine

• 561 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 422 (literal)

Rivista

• Biochemical journal (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• CNR, IBB, I-80134 Naples, Italy Univ Naples Federico 2, Dipartimento Sci Biol, I-80134 Naples, Italy Univ Sannio, Dipartimento Sci Biol & Ambientali, I-82100 Benevento, Italy BioGeM Consortium, I-83031 Ariano Irpino, Italy Ctr Endocrinol & Oncol Sperimentale, I-80131 Naples, Italy Univ Naples Federico 2, Dipartimento Biol & Patol Cellulare & Mol, I-80131 Naples, Italy (literal)

Titolo

• Generation and functional characterization of a BCL10-inhibitory peptide that represses NF-kappaB activation (literal)

Abstract

• The molecular complex containing BCL10 and CARMA [CARD (caspase recruitment domain)-containing MAGUK (membrane-associated guanylate kinase)] proteins has recently been identified as a key component in the signal transduction pathways that regulate activation of the transcription factor NF-kappa B (nuclear factor kappa B) in lymphoid and non-lymphoid cells. Assembly of complexes containing BCL10 and CARMA proteins relies on homophilic interactions established between the CARDs of these proteins. In order to identify BCL 10-inhibitory peptides, we have established a method of assaying peptides derived from the CARD of BCL10 in binding competition assays of CARD-CARD self-association. By this procedure, a short peptide corresponding to amino acid residues 91-98 of BCL10 has been selected as an effective inhibitor of protein self-association. When tested in cell assays for its capacity to block NF-kappa B activation, this peptide represses activation of NF-kappa B mediated by BCL10, CARMA3 and PMA/ionomycin stimulation. Collectively, these results indicate that residues 91-98 of BCL10 are involved in BCL10 self-association and also participate in the interaction with external partners. We also show that blocking of the CARD of BCL10 may potentially be used for the treatment of pathological conditions associated with inappropriate NF-kappa B activation. (literal)

Prodotto di

• Nuove molecole ad azione farmacologica per il trattamento del diabete di tipo II (PM.P01.005.004) (Modulo)
• Institute of biostructure and bioimaging (IBB) (Istituto)
• Istituto per l'endocrinologia e l'oncologia \"Gaetano Salvatore\" (IEOS) (Istituto)
• Strategie innovative per la terapia e la diagnosi dei tumori (SV.P15.001.005) (Modulo)

Autore CNR

• DOMENICO LIGUORO (Persona)
• SIMONA MARIA MONTI (Unità di personale interno)
• MENOTTI RUVO (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "Generation and functional characterization of a BCL10-inhibitory peptide that represses NF-kappaB activation" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• SIMONA MARIA MONTI (Unità di personale interno)
• MENOTTI RUVO (Unità di personale interno)
• DOMENICO LIGUORO (Persona)

Prodotto

• Istituto per l'endocrinologia e l'oncologia \"Gaetano Salvatore\" (IEOS) (Istituto)
• Institute of biostructure and bioimaging (IBB) (Istituto)
• Strategie innovative per la terapia e la diagnosi dei tumori (SV.P15.001.005) (Modulo)
• Nuove molecole ad azione farmacologica per il trattamento del diabete di tipo II (PM.P01.005.004) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Biochemical journal (Rivista)

Insieme di parole chiave di

• Parole chiave di "Generation and functional characterization of a BCL10-inhibitory peptide that represses NF-kappaB activation" (Insieme di parole chiave)