Synthesis, characterization and cytotoxic activity of substituted benzyl iminoether Pt(II) complexes of the type cis- and trans-[PtCl2{E-N(H)=C(OMe)CH2-C6H4-p-R}(2)] (R = Me, OMe, F). X-ray structure of trans-[PtCl2{E-N(H)=C(OMe)CH2-C6H4-p-F}(2)] (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Synthesis, characterization and cytotoxic activity of substituted benzyl iminoether Pt(II) complexes of the type cis- and trans-[PtCl2{E-N(H)=C(OMe)CH2-C6H4-p-R}(2)] (R = Me, OMe, F). X-ray structure of trans-[PtCl2{E-N(H)=C(OMe)CH2-C6H4-p-F}(2)] (Articolo in rivista) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Alternative label

• Mazzega Sbovata S. 1, Bettio F.2, Marzano C. 2, Tassan A. 1,Mozzon M.1, Bertani R. 1, Benetollo F.3, Michelin R. A. 1 (2008)
  Synthesis, characterization and cytotoxic activity of substituted benzyl iminoether Pt(II) complexes of the type cis- and trans-[PtCl2{E-N(H)=C(OMe)CH2-C6H4-p-R}(2)] (R = Me, OMe, F). X-ray structure of trans-[PtCl2{E-N(H)=C(OMe)CH2-C6H4-p-F}(2)]
  in Journal of inorganic biochemistry
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Mazzega Sbovata S. 1, Bettio F.2, Marzano C. 2, Tassan A. 1,Mozzon M.1, Bertani R. 1, Benetollo F.3, Michelin R. A. 1 (literal)

Pagina inizio

• 882 (literal)

Pagina fine

• 891 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 102 (literal)

Rivista

• Journal of inorganic biochemistry (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1. Department of Chemical Processes of Engineering, University of Padova. 2. Department of Pharmaceutical Sciences, University of Padova. 3. ICIS – C.N.R., Padova (literal)

Titolo

• Synthesis, characterization and cytotoxic activity of substituted benzyl iminoether Pt(II) complexes of the type cis- and trans-[PtCl2{E-N(H)=C(OMe)CH2-C6H4-p-R}(2)] (R = Me, OMe, F). X-ray structure of trans-[PtCl2{E-N(H)=C(OMe)CH2-C6H4-p-F}(2)] (literal)

Abstract

• New substituted benzyl iminoether derivatives of the type cis- and trans-[PtCl2{E-N(H)=C(OMe)CH2-C6H4-p-R}(2)] (R = Me (1a, 2a), OMe (3a, 4a), F (5a, 6a)) have been synthesized and characterized by elemental analyses, FT-IR spectroscopy and NMR techniques. The iminoether ligands are in the E configuration, which is stable in solution and in the solid state, as confirmed by the H-1 NMR data. Complex trans-[PtCl2{E-N(H)=C(OMe)CH2-C6H4-p-F}(2)] (6a) was also characterized by an X-ray diffraction study. Complexes 1 a-6a have been tested against a panel of human tumor cell lines in order to evaluate their cytotoxic activity. cis-Isomers were significant more potent than the corresponding trans-isomers against all tumor cell lines tested; moreover, complexes la and 5a showed IC50 values from about 2-fold to 6-fold lower than those exhibited by cisplatin, used as reference platinum anticancer drug. (C) 2007 Elsevier Inc. All rights reserved. (literal)

Prodotto di

• Istituto di chimica inorganica e delle superfici (ICIS) (Istituto)
• Progettazione e sintesi di sistemi molecolari inorganici per diagnosi e terapia (PM.P01.019.002) (Modulo)
• Progettazione di Nuovi Precursori Molecolari per Nanosistemi e Ottimizzazione del Processo MOCVD per la Fabbricazione e/o Modifica delle Funzionalità delle Superfici (PM.P05.001.001) (Modulo)

Autore CNR

• FRANCO BENETOLLO (Unità di personale interno)

Insieme di parole chiave

• Keywords of "Synthesis, characterization and cytotoxic activity of substituted benzyl iminoether Pt(II) complexes of the type cis- and trans-[PtCl2{E-N(H)=C(OMe)CH2-C6H4-p-R}(2)] (R = Me, OMe, F). X-ray structure of trans-[PtCl2{E-N(H)=C(OMe)CH2-C6H4-p-F}(2)]" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di chimica inorganica e delle superfici (ICIS) (Istituto)
• Progettazione e sintesi di sistemi molecolari inorganici per diagnosi e terapia (PM.P01.019.002) (Modulo)
• Progettazione di Nuovi Precursori Molecolari per Nanosistemi e Ottimizzazione del Processo MOCVD per la Fabbricazione e/o Modifica delle Funzionalità delle Superfici (PM.P05.001.001) (Modulo)

Autore CNR di

• FRANCO BENETOLLO (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of inorganic biochemistry (Rivista)

Insieme di parole chiave di

• Keywords of "Synthesis, characterization and cytotoxic activity of substituted benzyl iminoether Pt(II) complexes of the type cis- and trans-[PtCl2{E-N(H)=C(OMe)CH2-C6H4-p-R}(2)] (R = Me, OMe, F). X-ray structure of trans-[PtCl2{E-N(H)=C(OMe)CH2-C6H4-p-F}(2)]" (Insieme di parole chiave)