Selective nicotinic acetylcholine receptor subunit deficits identified in Alzheimer's disease, Parkinson's disease and dementia with Lewy bodies by immunoprecipitation (Articolo in rivista)

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  • Selective nicotinic acetylcholine receptor subunit deficits identified in Alzheimer's disease, Parkinson's disease and dementia with Lewy bodies by immunoprecipitation (Articolo in rivista) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.nbd.2006.04.005 (literal)
Alternative label
  • Gotti C.(2); Moretti M.(2); Bohr I.(1); Ziabreva I.(1); Vailati S.(2); Longhi R.(2); Riganti L.(2); Gaimarri A.(2); McKeith I.G.(4); Perry R.H.(1); Aarsland D.; Larsen J.P.(4); Sher E.(5); Beattie R.(1); Clementi F.(2); Court J.A(1) . (2006)
    Selective nicotinic acetylcholine receptor subunit deficits identified in Alzheimer's disease, Parkinson's disease and dementia with Lewy bodies by immunoprecipitation
    in Neurobiology of disease
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Gotti C.(2); Moretti M.(2); Bohr I.(1); Ziabreva I.(1); Vailati S.(2); Longhi R.(2); Riganti L.(2); Gaimarri A.(2); McKeith I.G.(4); Perry R.H.(1); Aarsland D.; Larsen J.P.(4); Sher E.(5); Beattie R.(1); Clementi F.(2); Court J.A(1) . (literal)
Pagina inizio
  • 481 (literal)
Pagina fine
  • 489 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 23 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1. Newcastle Gen Hosp, Inst Ageing & Hlth, IAH Res Labs, Newcastle Upon Tyne NE4 6BE, Tyne & Wear, England 2. CNR, Inst Neurosci, Cellular & Mol Pharmacol Sect,Dept Med Pharmacol,Univ Milan, I-20129 Milan, Italy 3. Newcastle Gen Hosp, Dept Neuropathol, Newcastle Upon Tyne NE4 6BE, Tyne & Wear, England 4. Stavanger Univ Hosp, Ctr Movement Disorders, Stavanger, Norway 5. Eli Lilly & Co, Lilly Res Ctr, Windlesham GU20 6PH, Surrey, England (literal)
Titolo
  • Selective nicotinic acetylcholine receptor subunit deficits identified in Alzheimer's disease, Parkinson's disease and dementia with Lewy bodies by immunoprecipitation (literal)
Abstract
  • Antibodies raised against human alpha 2-6 and beta 2-4 nicotinic receptor subunits were utilized to fractionate H-3-epibatidine binding in human temporal cortex and striatum. The predominant receptor subtypes in both regions contained alpha 4 and beta 2 subunits. In normal cortex, 10% of binding was also associated with alpha 2 subunits, whereas in the striatum, contributions by alpha 6 (17%) and beta 3 (23%) were observed. Minimal binding (<= 5%) was associated with alpha 3. In Alzheimer's disease and dementia with Lewy bodies, cortical loss of binding was associated with reductions in alpha 4 (50%, P < 0.01) and beta 2 (30-38%, P < 0.05). in Parkinson's disease and dementia with Lewy bodies, striatal deficits in alpha 6 (91 and 59% respectively, P < 0.01) and beta 3 (72 and 75%, P < 0.05) tended to be greater than for alpha 4 and beta 2 (50-58%, P < 0.05). This study demonstrates distinct combinations of subunits contributing to heteromeric nicotinic receptor binding in the human brain that are area/pathway specific and differentially affected by neurodegeneration (literal)
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