Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide (Articolo in rivista) (literal)

Anno

• 2009-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1002/prot.22144 (literal)

Alternative label

• Di Fiore, Anna; Monti, Simona Maria; Hilvo, Mika; Parkkila, Seppo; Romano, Vincenza; Scaloni, Andrea; Pedone, Carlo; Scozzafava, Andrea; Supuran, Claudiu T.; De Simone, Giuseppina (2009)
  Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide
  in Proteins (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Di Fiore, Anna; Monti, Simona Maria; Hilvo, Mika; Parkkila, Seppo; Romano, Vincenza; Scaloni, Andrea; Pedone, Carlo; Scozzafava, Andrea; Supuran, Claudiu T.; De Simone, Giuseppina (literal)

Pagina inizio

• 164 (literal)

Pagina fine

• 175 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 74 (literal)

Rivista

• Proteins (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• CNR, Ist Biostrutture & Bioimmagini, I-80134 Naples, Italy Univ Tampere, Inst Med Technol, FIN-33101 Tampere, Finland Univ Tampere, Sch Med, FIN-33101 Tampere, Finland Univ Tampere, Tampere Univ Hosp, FIN-33101 Tampere, Finland CNR, ISPAAM, Lab Prote & Spettrometria Massa, I-80147 Naples, Italy Univ Florence, Chim Bioorgan Lab, I-50019 Florence, Italy (literal)

Titolo

• Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide (literal)

Abstract

• The cytosolic isoform XIII is a recently discovered member of the human carbonic anhydrase (hCA, EC 4.2.1.1) family. It is selectively expressed among other tissues in the reproductive organs, where it may control pH and ion balance regulation, ensuring thus proper fertilization conditions. The authors report here the X-ray crystallographic structure of this isozyme in the unbound state and in complex with a classical sulfonamide inhibitor, namely acetazolamide. A detailed comparison of the obtained structural data with those already reported for other CA isozymes provides novel insights into the catalytic properties of the members of this protein family. On the basis of the inhibitory properties of acetazolamide against various cytosolic/transmembrane isoforms and the structural differences detected within the active site of the various CA isoforms, further prospects for the design of isozyme-specific CA inhibitors are here proposed. (literal)

Prodotto di

• Institute of biostructure and bioimaging (IBB) (Istituto)
• Institute for animal production system in mediterranean environment (ISPAAM) (Istituto)
• Metodologie genomiche e proteomiche applicate al sistema zootecnico ed agroindustriale (AG.P01.015.001) (Modulo)
• Targeting e inibizione dell'angiogenesi per mezzo di antagonisti del recettore Flt-1 di VEGF/PlGF (PM.P01.007.001) (Modulo)

Autore CNR

• GIUSEPPINA DE SIMONE (Unità di personale interno)
• CARLO PEDONE (Persona)
• ANDREA SCALONI (Persona)
• SIMONA MARIA MONTI (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• GIUSEPPINA DE SIMONE (Unità di personale interno)
• SIMONA MARIA MONTI (Unità di personale interno)
• ANDREA SCALONI (Persona)
• CARLO PEDONE (Persona)

Prodotto

• Institute of biostructure and bioimaging (IBB) (Istituto)
• Institute for animal production system in mediterranean environment (ISPAAM) (Istituto)
• Targeting e inibizione dell'angiogenesi per mezzo di antagonisti del recettore Flt-1 di VEGF/PlGF (PM.P01.007.001) (Modulo)
• Metodologie genomiche e proteomiche applicate al sistema zootecnico ed agroindustriale (AG.P01.015.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Proteins (Rivista)

Insieme di parole chiave di

• Parole chiave di "Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide" (Insieme di parole chiave)