Protective activation of the endocannabinoid system during ischemia in dopamine neurons. (Articolo in rivista)

Type
Label
  • Protective activation of the endocannabinoid system during ischemia in dopamine neurons. (Articolo in rivista) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.nbd.2006.04.010 (literal)
Alternative label
  • Melis M., Pillolla G., Bisogno T., Minassi A., Petrosino S., Perra S., Muntoni A.L., Lutz B., Gessa G.L., Marsicano G., Di Marzo V., Pistis M. (2006)
    Protective activation of the endocannabinoid system during ischemia in dopamine neurons.
    in Neurobiology of disease
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Melis M., Pillolla G., Bisogno T., Minassi A., Petrosino S., Perra S., Muntoni A.L., Lutz B., Gessa G.L., Marsicano G., Di Marzo V., Pistis M. (literal)
Pagina inizio
  • 15 (literal)
Pagina fine
  • 27 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 24 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 13 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 1 (literal)
Note
  • PubMe (literal)
  • ISI Web of Science (WOS) (literal)
  • Scopu (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • (1) Centre of Excellence ''Neurobiology of Addiction'', University of Cagliari, Italy (2) B.B. Brodie Department of Neuroscience, University of Cagliari, Monserrato, Italy (3) CNR Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Pozzuoli (NA), Italy (4) CNR Institute of Neuroscience-Cagliari, University of Cagliari, Monserrato, Italy (5) Department of Physiological Chemistry, Johannes Gutenberg University, Mainz, Germany (literal)
Titolo
  • Protective activation of the endocannabinoid system during ischemia in dopamine neurons. (literal)
Abstract
  • Endocannabinoids act as neuroprotective molecules promptly released in response to pathological stimuli. Hence, they may represent one component of protection and/or repair mechanisms mobilized by dopamine (DA) neurons under ischemia. Here, we show that the endocannabinoid 2-arachidonoyl-glycerol (2-AG) plays a key role in protecting DA neurons from ischemia-induced altered spontaneous activity both in vitro and in vivo. Accordingly, neuroprotection can be elicited through moderate cannabinoid receptor type-1 (CB1) activation. Conversely, blockade of endocannabinoid actions through CB1 receptor antagonism worsens the outcome of transient ischemia on DA neuronal activity. These findings indicate that 2-AG mediates neuroprotective actions by delaying damage and/or restoring function of DA cells through activation of presynaptic CB1 receptors. Lastly, they point to CB1 receptors as valuable targets in protection of DA neurons against ischemic injury and emphasize the need for a better understanding of endocannabinoid actions in the fine control of DA transmission. (literal)
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