Ferulic Acid-loaded lipid nanostructures as drug delivery systems for Alzheimer's disease: preparation, characterization and cytotoxicity studies (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Ferulic Acid-loaded lipid nanostructures as drug delivery systems for Alzheimer's disease: preparation, characterization and cytotoxicity studies (Articolo in rivista) (literal)

Anno

• 2009-01-01T00:00:00+01:00 (literal)

Alternative label

• Bondì M.L.; Montana G.; Craparo E.F.; Picone P.; Capuano G.; Di Carlo M.; Giammona G. (2009)
  Ferulic Acid-loaded lipid nanostructures as drug delivery systems for Alzheimer's disease: preparation, characterization and cytotoxicity studies
  in Current nanoscience (Print); Bentham Science Publishers Ltd., Sharjah (Emirati Arabi Uniti)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Bondì M.L.; Montana G.; Craparo E.F.; Picone P.; Capuano G.; Di Carlo M.; Giammona G. (literal)

Pagina inizio

• 26 (literal)

Pagina fine

• 32 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 5 (literal)

Rivista

• Current nanoscience (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 7 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• ISMN-CNR, via Ugo La Malfa, 153, 90146 Palermo ; IBIM-CNR, via Ugo La Malfa, 153, 90146 Palermo, Italy ; Dipartimento di Chimica e Tecnologie Farmaceutiche, University of Palermo, via Archirafi 32, 90123 Palermo, Italy (literal)

Titolo

• Ferulic Acid-loaded lipid nanostructures as drug delivery systems for Alzheimer's disease: preparation, characterization and cytotoxicity studies (literal)

Abstract

• Ferulic acid (FA), a phenolic compound with a significant antioxidant activity in Alzheimer's disease, was entrapped into several solid lipid nanoparticles (SLN and NLC) by using the microemulsion technique. Stable SLN and NLC formulations having mean size ranging between 94-140 nm and high zeta potential were obtained. The SLN sample obtained by using as lipid matrix Compritol 888 ATO was chosen for further characterization because, among these particles, showed high Loading Capacity (LC%) and the best characteristics in terms of size, PDI, and drug release profile. Empty SLN showed no cytotoxicity on human neuroblastoma cells (LAN 5) at tested concentrations and the ability to penetrate into these cells. Moreover, cells treated with FA-loaded SLN showed a higher reduced ROS production than cells treated with free FA. These findings demonstrate that FA-loaded SLN possess a higher protective activity than free FA against oxidative stress induced in neurons and suggest that SLN are excellent carriers to transport FA into the cells. (literal)

Editore

• Bentham Science Publishers Ltd. (Editore)

Prodotto di

• Istituto per lo studio dei materiali nanostrutturati (ISMN) (Istituto)
• Processi di aggregazione, misfolding di proteine e neuropatologie (ME.P01.014.004) (Modulo)
• Sintesi e crescita di film e superfici nanostrutturate (PM.P05.004.002) (Modulo)
• Istituto di biomedicina e di immunologia molecolare \"Alberto Monroy\" (IBIM) (Istituto)

Autore CNR

• MARIA LUISA BONDI' (Unità di personale interno)
• PASQUALE PICONE (Persona)
• GIOVANNA MONTANA (Persona)
• MARTA DI CARLO (Unità di personale interno)

Incoming links:

Prodotto

• Istituto di biomedicina e di immunologia molecolare \"Alberto Monroy\" (IBIM) (Istituto)
• Istituto per lo studio dei materiali nanostrutturati (ISMN) (Istituto)
• Sintesi e crescita di film e superfici nanostrutturate (PM.P05.004.002) (Modulo)
• Processi di aggregazione, misfolding di proteine e neuropatologie (ME.P01.014.004) (Modulo)

Autore CNR di

• MARTA DI CARLO (Unità di personale interno)
• GIOVANNA MONTANA (Persona)
• PASQUALE PICONE (Persona)
• MARIA LUISA BONDI' (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Current nanoscience (Rivista)

Editore di

• Bentham Science Publishers Ltd. (Editore)