Piezoelectric sensors for dioxins: a biomimetic approach (Articolo in rivista)

Type
Label
  • Piezoelectric sensors for dioxins: a biomimetic approach (Articolo in rivista) (literal)
Anno
  • 2004-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.bios.2004.06.048 (literal)
Alternative label
  • Mascini, M (a)(e); Macagnano, A (b); Monti, D (c); Del Carlo, M (a); Paolesse, R (b)(c); Chen, B (d)(e); Warner, P (e); D'Amico, A (b)(f); Di Natale, C (b)(f); Compagnone, D (a) (2004)
    Piezoelectric sensors for dioxins: a biomimetic approach
    in Biosensors & bioelectronics
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Mascini, M (a)(e); Macagnano, A (b); Monti, D (c); Del Carlo, M (a); Paolesse, R (b)(c); Chen, B (d)(e); Warner, P (e); D'Amico, A (b)(f); Di Natale, C (b)(f); Compagnone, D (a) (literal)
Pagina inizio
  • 1203 (literal)
Pagina fine
  • 1210 (literal)
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  • 20 (literal)
Rivista
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  • 6 (literal)
Note
  • ISI Web of Science (WOS) (literal)
  • Scopu (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • a Dipartimento di Scienze degli Alimenti, Università di Teramo, 64023 Teramo, Italy b IMM-CNR Sezione di Roma, 00133 Roma, Italy c Dipartimento di Scienze e Tecnologie Chimiche, Universit Tor Vergata, 00133 Roma, Italy d Department of Chemistry, Sheffield University, Sheffield S10 2TN, UK e Instute of BioScience and Technology, Cranfield University at Silsoe, Bedfordshire MK43 0AL, UK f Dipartimento di Ingegneria Elettronica, Universit Tor Vergata, 00133 Roma, Italy (literal)
Titolo
  • Piezoelectric sensors for dioxins: a biomimetic approach (literal)
Abstract
  • The aim of this work was to design a fast, cheap and easy to use analytical system for dioxins. Piezoelectric sensors coupled with the pentapeptides as biomimetic traps (the receptors), selective for the dioxins, were used for the realisation of this analytical system. A methodology to select specific receptors among all possible pentapeptides randomly generated was represented by the use of molecular modelling software. Three peptides called later on A, B and C (A:[N]Asn-Phe-Gln-Gly-Ile[C]; B:[N]Asn-Phe-Gln-Gly-Gln[C]; C:[N]Asn-Phe-Gln-Gly-Phe[C]), were selected and evaluated for their potential usage as artificial receptors in solid-gas analysis by using a quartz crystal microbalance (QCM) sensors array. The peptide sequences were functionalised by two terminal cysteine residues in order to achieve a covalent interaction with the QCM gold surface. A manganese-porphyrin complex and two other pentapeptides, a pentaglutamine (pentapeptide D) and a pentalysine (pentapeptide E), were used as negative control sensors. The QCM sensors (A, B and C) gave a good linearity against different sample concentrations of the 2,3,7,8-tetrachlorinated dibenzo-p-dioxin (TCDD) and a mixture of dioxins. In particular, the selectivity against 2,3,7,8-TCDD was nicely correlated to the estimated binding energy of the receptors calculcated by computational modelling. The cross-reactivity of the system was quantified using commercial polychlorinated biphenyls (PCBs) mixtures (dioxin-like compounds). (literal)
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