Biomimetic chemistry on tandem protein/lipid damages under reductive radical stress (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Biomimetic chemistry on tandem protein/lipid damages under reductive radical stress (Articolo in rivista) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.2533/chimia.2008.721 (literal)

Alternative label

• Scaloni, Andrea (5); Ferreri, Carla (5); Torreggiani, Armida (5); Salzano, Anna Maria (1); CHATGILIALOGLU, CHRYSSOSTOMOS (6); Capdevila, Mercè (4); Atrian, Silvia (3); Bobrowski, Krzysztof (2); Houée-Levin, Chantai (6) (2008)
  Biomimetic chemistry on tandem protein/lipid damages under reductive radical stress
  in CHIMIA International Journal for Chemistry
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Scaloni, Andrea (5); Ferreri, Carla (5); Torreggiani, Armida (5); Salzano, Anna Maria (1); CHATGILIALOGLU, CHRYSSOSTOMOS (6); Capdevila, Mercè (4); Atrian, Silvia (3); Bobrowski, Krzysztof (2); Houée-Levin, Chantai (6) (literal)

Pagina inizio

• 721 (literal)

Pagina fine

• 727 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 62 (literal)

Rivista

• CHIMIA International Journal for Chemistry (Rivista)

Note

• ISI Web of Science (WOS) (literal)
• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• (1) Proteomics and Mass Spectrometry Laboratory - ISPAAM; (2) Institute of Nuclear Chemistry and Technology - ; (3) Departament de Genètica - Facultat de Biologia; (4) Departament de Química - Facultat de Ciències; (5) ISOF - Consiglio Nazionale Delle Ricerche; (6) Laboratoire de Chimie Physique - UMR 8000 (literal)

Titolo

• Biomimetic chemistry on tandem protein/lipid damages under reductive radical stress (literal)

Abstract

• The study of radical stress in the biological environment needs a comprehensive vision of all possible reactive species and their mechanisms. Among them, reductive stress is evaluated for its selective target of sulfurcontaining compounds. The selective attack of reducing species like Ho atoms or eaq -/H+ to sulfur-containing amino acid residues has been proved in different substrates, peptides and proteins. The transformations include methionine to ?-aminobutyric acid and cysteine/cystine residues to alanine, as recognized in several sequences so far, such as RNase A, lysozyme, Met-enkephalin, amyloid ?-peptide and metallothioneins. The amino acid desulfurization is accompanied by the formation of low-molecular-weight sulfur-centered radicals that may cause geometrical cis-trans isomerization of unsaturated fatty acid residues in lipid bilayer. Thus, tandem protein/lipid damage is accomplished. Progress in research has given us a more comprehensive overview of the protein modifications and their roles, and the chemical biology approach will make its vital contribution to the study of free radical reactions, linking chemistry to biology and medicine. (literal)

Prodotto di

• Institute for animal production system in mediterranean environment (ISPAAM) (Istituto)
• Modelli biomimetici di stress radicalico e biomarcatori correlati (PM.P06.006.001) (Modulo)
• Metodologie genomiche e proteomiche applicate al sistema zootecnico ed agroindustriale (AG.P01.015.001) (Modulo)
• Institute for organic syntheses and photoreactivity (ISOF) (Istituto)

Autore CNR

• CHRYSSOSTOMOS CHATGILIALOGLU (Unità di personale interno)
• CARLA FERRERI (Unità di personale interno)
• ARMIDA TORREGGIANI (Unità di personale interno)
• ANDREA SCALONI (Persona)
• ANNA MARIA SALZANO (Persona)

Insieme di parole chiave

• Keywords of "Biomimetic chemistry on tandem protein/lipid damages under reductive radical stress" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute for organic syntheses and photoreactivity (ISOF) (Istituto)
• Institute for animal production system in mediterranean environment (ISPAAM) (Istituto)
• Metodologie genomiche e proteomiche applicate al sistema zootecnico ed agroindustriale (AG.P01.015.001) (Modulo)
• Modelli biomimetici di stress radicalico e biomarcatori correlati (PM.P06.006.001) (Modulo)

Autore CNR di

• CARLA FERRERI (Unità di personale interno)
• ANNA MARIA SALZANO (Persona)
• ANDREA SCALONI (Persona)
• CHRYSSOSTOMOS CHATGILIALOGLU (Unità di personale interno)
• ARMIDA TORREGGIANI (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• CHIMIA International Journal for Chemistry (Rivista)

Insieme di parole chiave di

• Keywords of "Biomimetic chemistry on tandem protein/lipid damages under reductive radical stress" (Insieme di parole chiave)