Inactivation of methicillin-resistant Staphylococcus aureus (MRSA) by liposome -delivered photosensitising agents (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Inactivation of methicillin-resistant Staphylococcus aureus (MRSA) by liposome -delivered photosensitising agents (Articolo in rivista) (literal)

Anno

• 2006-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.jphotobiol.2005.12.008 (literal)

Alternative label

• Ferro S.; Ricchelli F.; Mancini G.; Tognon G.; Jori G. (2006)
  Inactivation of methicillin-resistant Staphylococcus aureus (MRSA) by liposome -delivered photosensitising agents
  in Journal of photochemistry and photobiology. B, Biology (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Ferro S.; Ricchelli F.; Mancini G.; Tognon G.; Jori G. (literal)

Pagina inizio

• 98 (literal)

Pagina fine

• 104 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 83 (literal)

Rivista

• Journal of photochemistry and photobiology. B, Biology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 2 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• CNR University (literal)

Titolo

• Inactivation of methicillin-resistant Staphylococcus aureus (MRSA) by liposome -delivered photosensitising agents (literal)

Abstract

• The uptake of two photosensitising agents (hematoporphyrin and chlorophyll a) by a highly pathogenic bacterium, namely methicillin-resistant Staphylococcus aureus (MRSA), has been studied by using unilamellar liposomes of different size, fluidity and electric charge as carriers. Optimal results are obtained by using hematoporphyrin embedded in fluid cationic vesicles composed by the monocationic lipid N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium methylsulfate (DOTAP), which yield an endocellular concentration of photosensitiser much higher than that obtained by incubation of the cells with the free porphyrin, yet promote a tighter binding and a more efficient photoinactivation of MRSA. Apparently, the photosensitiser is successfully transferred from the liposome to the bacterial cells when the presence of the tetrapyrrolic derivative does not appreciably perturb the native three-dimensional organisation of the lipid vesicle, such as it occurs with hematoporphyrin. On the other hand, chlorophyll, which causes a marked structural alteration of the DOTAP vesicles as shown by electron microscopy and fluorescence anisotropy measurements, does not show any detectable photocytotoxicity toward MRSA, contrary to what observed for the free dye. (literal)

Prodotto di

• Metodologie, nanoparticelle e nutraceutici in nanomedicina (PM.P05.002.001) (Modulo)
• Neuroscienze (ME.P02.016.001) (Modulo)
• Istituto di metodologie chimiche (IMC) (Istituto)

Autore CNR

• GIUSEPPE TOGNON (Unità di personale interno)
• FERNANDA RICCHELLI (Unità di personale interno)
• GIOVANNA MANCINI (Unità di personale interno)

Insieme di parole chiave

• Keywords of "Inactivation of methicillin-resistant Staphylococcus aureus (MRSA) by liposome -delivered photosensitising agents" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di metodologie chimiche (IMC) (Istituto)
• Metodologie, nanoparticelle e nutraceutici in nanomedicina (PM.P05.002.001) (Modulo)
• Neuroscienze (ME.P02.016.001) (Modulo)

Autore CNR di

• FERNANDA RICCHELLI (Unità di personale interno)
• GIOVANNA MANCINI (Unità di personale interno)
• GIUSEPPE TOGNON (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of photochemistry and photobiology. B, Biology (Rivista)

Insieme di parole chiave di

• Keywords of "Inactivation of methicillin-resistant Staphylococcus aureus (MRSA) by liposome -delivered photosensitising agents" (Insieme di parole chiave)